The use of metal nanoparticles as antibiotics for resistant pathogens has become a current topic of research. Biosyn-thesized nanoparticles are promising drugs as antibacterial agents by inhibiting bacteria from infectious diseases. Thisstudy aimed at the synthesis and characterization of silver nanoparticles (AgNPs) from AgNO 3 solution and Sida schim-periana Hochst. ex A. Rich leaves extract. The synthesized AgNPs were characterized by Fourier Transform Infrared (FTIR),Ultraviolet–Visible (UV–Vis) and X-ray diffraction (XRD) spectroscopic techniques and evaluated for antibacterial activi-ties against Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Escherichia coliand Klebsiella Pneumonia) bacteria by the disc diffusion method. The result indicated an initial color change that wasobserved below 400 nm for the leaves extract and 429 nm for AgNPs in the UV–Vis band supporting the synthesis ofsilver nanoparticles. The FTIR peaks at 3447, 1638 and 1413 cm −1 predict the hydroxyl, carbonyl and unsaturated C–Cbonds, respectively, in the plant leaves extract. The XRD analysis showed that the synthesized AgNPs were crystalline innature and face-centered cubic (FCC) structure with an average particle size of 26.27 nm. Furthermore, the synthesizednanoparticles showed antimicrobial activity to both types of bacteria, more significant being on Gram-negative bacteria(E. coli). In conclusion, the leaves extract of Sida schimperiana Hochst. ex A. Rich plant contains bioactive molecules thatare used in the reduction and stabilization of AgNPs as potential antibacterial agents.Keywords: Biosynthesis · Phytochemicals · Antimicrobial resistance · Medicinal plant · Resistant pathogens

This study introduces a highly sensitive electrochemical method for detecting paracetamol (PCT) in pharma-ceutical tablets and human serum samples, utilizing a glassy carbon electrode modified with alizarin red S (poly(ARS)/GCE). PCT is one of the most widely used analgesic and antipyretic drugs; however, its overdose orprolonged use can lead to severe liver and kidney damage. Therefore, the development of sensitive and reliablemethods for monitoring PCT levels in pharmaceutical formulations and biological fluids is crucial for ensuringdrug safety and effective therapeutic monitoring. Characterization of the electrode confirmed that the surfacemodification with a conductive and electroactive polymer film (poly(ARS)) significantly enhanced the effectiveelectrode surface area and reduced charge transfer resistance. Compared to the unmodified electrode, themodified electrode exhibited a well-resolved, irreversible redox peak at a significantly lower potential with asixfold increase in current, highlighting the catalytic efficiency of the modifier toward PCT. The electrochemicalbehavior of PCT was analyzed via cyclic voltammetry and square wave voltammetry, revealing significantlyenhanced sensitivity and selectivity due to the conductive polymer coating. Under optimized electrode conditionsquare wave voltammetric current response of poly(ARS)/GCE showed linear dependence on concentration of0.01–250.0 μM and an ultralow detection limit of 1.0 nM in phosphate buffer solution (pH 7.0). Analyticalapplication on real samples confirmed the method's accuracy, achieving recovery rates of 98.8–100.3 % forpharmaceutical tablets and human blood serum, even in the presence of potential interferents. The developedmethod provides a cost-effective and robust alternative for PCT quantification, with superior performancecompared to previously report electrochemical approaches.
Keywords: Paracetamol, Glassy carbon electrode, Alizarin red S, Cyclic voltammetry, Square wave voltammetry

Introduction: Growth monitoring and promotion services are strategies to promote child health and reduce child mortality. Even though Ethiopia is attempting different strategies to cope with the low rate of GMP utilization, the problem is still unresolved.
Objective: Determine the pooled proportion of GMP utilization and its contributing factors among children less than two years in Ethiopia.
Method: The review protocol was registered with PROSPERO, number CRD42023472746. The PRISMA-2020 statement guided the conduct of this review. Electronic databases and grey literature were used. Heterogeneity was evaluated using I2. Subgroup analysis was conducted. The random effect model was used to summarize the pooled effect sizes with their respective 95% CI with STATA version 17. To test the small study effect, the funnel plot and Egger’s test were applied.
Result: A total of seven (7) studies with 4027 participants were considered in this meta-analysis. The pooled proportion of GMP utilization reported by seven studies was 25.71% (95%CI: 24.39, 27.04). ANC follow-up (AOR = 2.11; 95% CI: 1.47, 2.76), PNC follow-up (AOR = 1.96; 95% CI: 1.44, 2.49), counseling (AOR = 2.88; 95% CI: 2.09, 3.68), maternal education (AOR = 2.89; 95% CI: 1.66, 4.13), paternal education (AOR = 3.78; 95% CI: 2.25, 5.32), family health card (AOR = 2.31; 95% CI: 1.67, 2.96), and mothers good knowledge towards GMP (AOR = 2.90; 95% CI: 1.72, 4.07) variables were positively associated with GMP service utilization.
Conclusion and recommendation: The pooled proportion of GMP remains low in Ethiopia. ANC and PNC follow-up, counseling, maternal and paternal education, family health cards, maternal knowledge towards GMP were significantly associated. Findings are essential for evidence-based policy making, intervention, and input for ongoing research.

Background: Digital health data hubs contribute significantly to finding the right solutions to health problems, which forms the basis for achieving sustainable development goals. However, in Ethiopia, the health system has been coming to one central hub for all data, there is limited evidence of health professionals' intentions to use these systems. Understanding their intentions is crucial, as this can significantly improve the advancement of digital health in healthcare organizations. This study assessed health professionals' intention to use digital health data hubs in hospitals in East Gojjam, northwest Ethiopia, in 2024.
Methods: A cross-sectional study design was used to conduct the study. Eleven hospitals were included in the study area. Using an a priori structural equation modeling sample size calculator, the total sample size was 616. Stratified proportional allocation sampling was performed. The study participants were selected using a systematic sample. Structural equation modeling (SEM) was used for the analysis. Because it is a more powerful multivariate technique for testing and evaluating multivariate causal relationships. The assumptions of SEM-like normality, average variance extracted (AVE), composite reliability (CR), Cronbach's alpha, confirmatory factor analysis (CFA), and model specifications were checked using Amos and Stata version 16.
Results: This study was conducted with a sample size of 616 healthcare professionals; 591 (95.94%) responded to the survey. The results showed that 57.69% (n = 341) of the healthcare professionals intended to use the digital health data hub. Further analysis showed that perceived usefulness (PU: β = 0.576, p = 0.000), perceived trust (PT: β = 0.116, p = 0.022), and attitude (β = 0.143, p = 0.043) significantly and positively influenced health professionals' intention to use digital health data hubs.
Conclusion: Overall, the findings showed that 42.31% of health professionals have low intention to use digital health data hubs. These shall be needed to improve their intentions to use digital health data hubs through targeted interventions. Therefore, focusing on critical factors, such as perceived usefulness, trust, and attitude are crucial factors to reinforce their intention to use the system. Additionally, overcoming implementation challenges and building trust is critical to the successful integration and use of digital health data hubs.

Introduction: Promoting healthy lifestyle behaviors during pregnancy is a crucial health promotion strategy that could reduce pregnancy-related complications that may harm women and their fetuses. However, very few studies have assessed the prevalence of health-promoting lifestyle behaviors among pregnant women in Ethiopia. This study aimed to evaluate the extent and associated factors of health-promoting lifestyle behaviors among pregnant women in public health institutions in Debre Markos, northwest Ethiopia.
Methods: An institutional-based cross-sectional study was conducted among 275 pregnant women who were recruited using a systematic random sampling technique from 19 April to 19 May 2021. A face-to-face interview-administered questionnaire was used to collect the data. The data were analyzed using SPSS version 25. Multivariable binary logistic regression was used to identify the factors associated with the outcome variable. adjusted odds ratio (AOR), with a 95% confidence interval (CI) were used to measure the strength of the associations at a p-value

ABSTRACT: β-Lactam antibiotics are employed to treat bacterial illnesses.Despite a high level of clinical success, they have encountered serious resistancethat demands a high-dose regimen and a new pharmacokinetic combination. Thisrequires continuous monitoring of their levels in pharmaceutical and biologicalsamples. In this study, an electrochemical sensor was developed for thedetermination of cephalexin (CLN) in pharmaceutical formulations and biologicalfluid samples. The sensors were developed by modifying a glassy carbon electrode(GCE) using a conducting polymer (dipicrylamine) by potentiodynamicelectropolymerization. Characterization (using cyclic voltammetry and electronimpedance spectroscopy) results revealed modification of the electrode surface,leading to an enhanced effective electrode surface area and their conductivity. Theappearance of an irreversible oxidative peak at much-reduced potential with 5-foldcurrent enhancement at a poly(dipicrylamine)-modified glassy carbon electrode(poly(DPA)/GCE) verified the electrocatalytic role toward CLN. Under optimizedconditions, a wider linear concentration range (5 × 10−8 to 3.0 × 10−4 M), lowest limit of detection (LoD) (2.5 nM), detectedamount of each tablet brand above 97.00% of the labeled value (showing excellent agreement between the detected amount andcompany label), and excellent % recovery results in pharmaceutical and biological samples were obtained with an excellentinterference recovery error of less than 4.05%. Its excellent accuracy, selectivity, reproducibility, and stabilities and only requiring asimple electrode modification step combined with its readily available and nontoxic modifier, which sets it apart from mostpreviously reported methods, have validated the present method’s potential applicability for determining CLN in biological andpharmaceutical samples.

Accurate regulation of the liquid level in a quadruple tank system (QTS) is not easy and imposes higherrequirements on control strategies, so the design of controllers in these systems is challenging dueto the difficulty of dynamic analysis of its nonlinear characteristics and parametric uncertainties.To overcome these problems in liquid level regulation and increase the robustness to the pumpcoefficients, this article proposes and investigates the use of an optimal hybrid fractional-ordertype-2 fuzzy-PID (OH-FO-T2F-PID) regulator using a combination of two bio-inspired evolutionaryoptimizers, namely augmented grey wolf optimizer and cuckoo search optimizer, which gives rise tothe new hybrid A-GWOCS algorithm. This control mechanism was chosen to facilitate the convergenceof the water liquids in the two tanks as quickly as possible to the corresponding required values. Inaddition, a collaborative optimization technique with several objectives is used to adjust the regulatorparameters. The capability and efficiency of the suggested regulator is first investigated throughcomputer simulation results and then confirmed by real-time control experimental results on the QTSbased on dSPACE 1104 computation engine. The findings showed that the suggested OH-FO-T2F-PIDregulator significantly outperformed both the optimized ADRC and the OH-FO-T1F-PID regulators.Specifically, it reduced the rising time by 17.02% and 95.21%, respectively, and the settling time by25.13% and 74.28%. Additionally, the designed OH-FO-T2F-PID regulator successfully eliminatedthe steady-state error and overshoot, enabling precise regulation of the QTS, and maintenance theliquid level at the desired set point under a wide range of working situations. The robustness of therecommended regulator is also studied by considering − 50% disturbance in the QTS parameters, andthe findings showed that the OH-FO-T2F-PID regulator is less susceptible to variations in parameters.Keywords: Quadruple tank system (QTS), Optimal hybrid fractional order type 2 fuzzy PID regulator,Hybrid A-GWOCSO algorithm, Multi-objective optimization, dSPACE 1104 computation engine

Background: Community-based health insurance (CBHI) is an emerging form of microhealth insurance that relies on theprinciple of solidarity, with community members pooling money to help with medical expenses. The level of household heads’satisfaction with CBHI schemes is more likely to affect their decision to remain enrolled and the entrance of new members.However, studies regarding household heads’ satisfaction with the CBHI schemes are scarce in Ethiopia. Therefore, this studyaimed to determine the level of satisfaction with CBHI schemes and associated factors among heads of households inNorthwest Ethiopia.Methods: A community-based cross-sectional study was conducted from March 1–30, 2022. A stratified random samplingtechnique with multistage sampling was used to select 604 study participants. A face-to-face interview was conducted using apretested structured questionnaire. Both bivariable and multivariable logistic regression analyses were conducted. An adjustedodds ratio (AOR) with 95% confidence intervals (CIs) was computed to evaluate the strength of the association, and variableswith a p value < 0 05 at a 95% CI were considered statistically significant.Results: This study found that about 56.1% of household heads were satisfied with the CBHI schemes. Being older age(AOR = 1 85; 95% CI: 1.17, 2.94), rural residence (AOR = 4 13; 95% CI: 2.24, 7.62), visited only health center (AOR = 0 34;95% CI: 0.20, 0.55), distance from a health facility (AOR = 3 18; 95% CI: 1.82, 5.55), agreement with prescribed drugs(AOR = 2 31; 95% CI: 1.36, 3.92), friendliness with healthcare provider (AOR = 3 65; 95% CI: 2.18, 6.10), and had a goodknowledge of benefit packages (AOR = 3 00; 95% CI: 1.93, 4.67) were significantly associated with household head satisfaction.Conclusion: The overall satisfaction of household heads with the CBHI schemes was good. The type of health facility visited,residence, age, distance from health facilities, relationship with healthcare providers, agreement with prescribed medications,and knowledge of community based health insurance were significantly associated with participants’ satisfaction. Thus, thesefindings suggest that improving access to healthcare services, fostering better relationships between healthcare providers andbeneficiaries, and enhancing awareness of CBHI benefits could further increase satisfaction levels among households.Keywords: community-based health insurance (CBHI); Ethiopia; household; satisfaction

This paper provides an in-depth analysis and performance evaluation of four Solar Radiance (SR)prediction models. The prediction is ensured for a period ranging from a few hours to several days ofthe year. These models are derived from four machine learning methods, namely the Feed-forwardBack Propagation (FFBP) method, Convolutional Feed-forward Back Propagation (CFBP) method,Support Vector Regression (SVR), and the hybrid deep learning (DL) method, which combinesConvolutional Neural Networks and Long Short-Term Memory networks. This combination results inthe CNN-LSTM model. Additionally, statistical indicators use Mean Squared Error (MSE), Root MeanSquared Error (RMSE), Mean Absolute Error (MAE), Mean Absolute Percentage Error (MAPE), andNormalized Root Mean Squared Error (nRMSE). Each indicator compares the predicted output by eachmodel above and the actual output, pre-recorded in the experimental trial. The experimental resultsconsistently show the power of the CNN-LSTM model compared to the remaining models in terms ofaccuracy and reliability. This is due to its lower error rate and higher detection coefficient (R2 = 0.99925).Keywords: Artificial neural networks, Convolutional neural network, Convolutional feed-forward backpropagation, Deep learning, Feed-forward back propagation, Long short-term memory, Solar radianceforecasting

Teff, a versatile crop, serves both as a food source and a cash crop in ethiopia. it is recognizedfor its potential to enhance the income of smallholder farmers, improve food security, andcontribute to sustainable development goals. This study aims to assess the impact of Teffcommercialization by smallholder farmers on food security. Both primary and secondary datawere used using the 2020/2021 cropping season. a three-stage sampling procedure was usedto draw 352 sample households. Food security was assessed using proxy indicators: householddietary diversity and food consumption score. The descriptive statistical results showed that182 (51.7%) and 170 (48.3%) sample households were subsistence, and commercializedhousehold heads respectively. notably, commercial farmers exhibited better household dietarydiversity (91.2%), whereas subsistence farmers scored lower in terms of food consumption(29.1%). Male household headship reduced hddS for commercializing farmers (−1.6); creditusage boosted hddS for commercialized groups (1.1), and livestock ownership improvedhddS for subsistence groups (0.21) in the second-stage endogenous switching regression.The model result also showed that, Teff commercialization positively impacted hddS and FcS,with average treatment effects of 3.81 and 4.46, respectively. Transitional heterogeneity resultsshowed that commercialized farmers had lower household dietary diversity (−0.47) and lowerfood consumption score (−14.19) than subsistence households. in light of these findings,encouraging smallholder farmers to transition from subsistence production to commercializationis crucial for supplementing their overall production. additionally, government efforts shouldfocus on raising awareness about nutrition-sensitive agricultural practices.
KEYWORDS: commercialization; endogenous Switching; Regression Model; Food Security; Smallholder; Teff