Multimetric assessment is one of the important tools for diagnosing, detecting and measuring impairment inecosystem function in lentic ecosystems. It enhances detection capabilities across a broader variety of stressorsand offers a more complete picture of ecological conditions than single metrics or biological indicators. In thiscontext, a diatom-based multimetric index (MMI-D) has been developed to evaluate the ecological health ofLake Hawassa. Physicochemical and benthic diatom sampling was conducted at nine sites along the lakeshore,representing varying levels of human disturbance, from February to November in2015 and 2016. The sampling siteswere classified a priori into three categories: minimally disturbed (three sites), moderately disturbed (three sites) andhighly disturbed (three sites). This classification, was based on a clustering analysis using the percent disturbancescore (PDS). Of the 24-diatom candidate metrics, only ten were chosen as core metrics for the development ofMMI-D, based on redundancy analysis, reaction to environmental conditions, percent discriminatory efficiency (%DE)and box plots. The newly established MMI-D clearly distinguished between reference and non-reference sites, andbetween the lake’s three clusters. The MMI-D’s performance was validated using independent data sets from lakesHawassa and Ziway and it demonstrated the best capability for discrimination between different disturbance levels.MMI-D 2-stage Least Squares (2SLS) regression analysis revealed an inverse but robust connection with the PDS,indicating its responsiveness to Lake Hawassa habitat quality degradation (n = 9, R2 = 0.921, p < 0.001). The MMI-Drevealed a high %DE (95.1%) and a negative but significant connection with nutrients, total suspended solids (TSS),and turbidity (R2 > 0.6; p < 0.05). Generally, it can be concluded that this index is a powerful tool that could assistendusers by providing a practical method for measuring the ecological quality of Lake Hawassa.Keywords: benthic diatoms, ecological quality, Lake Ziway, redundancy analysis, validation

Two new oligomer mixed ligand complexes, comprising 21 ([Co21(phen)42(bipy)21]Cl42 (C2)) and 100 monomerunits ([Co100(phen)200(bipy)100]Cl200 (C3)) were synthesized. These complexes, designated as [Co21(phen)42(-bipy)21]Cl42 (C2) and [Co100(phen)200(bipy)100]Cl200 (C3), were employed for the modification of a glassycarbon electrode (GCE) to detect ciprofloxacin (CPF) in tablet formulations and human urine samples. Bypotentiodynamic deposition, the modified electrodes (poly(C2)/GCE) and (poly(C3)/GCE) were prepared,forming a conductive electroactive film on the GCE surface. The modified electrodes were characterized usingcyclic voltammetry and electrochemical impedance spectroscopy, which revealed an increased effective surfacearea and a significant reduction in charge transfer resistance of the electrode. An oxidative peak at a lowerpotential with a six-fold increase in peak current was observed at the poly(C2)/GCE. The absence of a reductivepeak in the reverse scan indicated the irreversibility of the electrochemical oxidation of CPF. The correlationcoefficient between the peak current and the square root of the scan rate indicated that CPF oxidation at the poly(C2)/GCE was primarily controlled by diffusion mass transport. With a detection limit of 3.4 × 10 9 M, thevoltammetric current response of CPF at the poly(C2)/GCE under optimal circumstances showed a linear trendwith concentrations ranging from 5.0 × 10 8 to 2.0 × 10 4 M. It was discovered that the CPF levels in theexamined tablet brands fell between 98.35 % and 101.30 % of their stated ranges. The recovery results for tabletand urine samples ranged from 99.44 % to 99.95 % and 99.25 % to 100.51 %, respectively, with interferencerecovery showing an error of less than 4.73 %. When it came to determining CPF in tablet formulations andhuman urine samples, the new approach outperformed recently published voltammetric methods. This superi-ority can be attributed to the simplicity of the electrode modification step, the lowest limit of detection, and areasonably wide linear dynamic range.
Keywords: Electrochemical determination; Ciprofloxacin; Poly(μ-4,4′-bipyridine(bis(1,10-phenanthroline))cobalt(II)chloride)); Glassy carbon electrodeTablet formulations

Executive Summary Concerns over chemical contaminants and toxins in local foods and beverages have been raised recently. These days, chronic illness is more common, and toxicants and other contaminants found in food and drink have been linked to many documented fatalities. The chemical toxicants that will be analyzed in this study include acrylamide (a processing toxicant arising from deep roasting of food samples), aflatoxin B1 (a poisonous chemical discharged by mold and fungi), pesticide residues (resulting from pesticide application to cereal, vegetable, and fruits), and methanol (a chemical toxicant produced by spontaneous fermentation of local alcoholic beverages). The acrylamide content of the food samples will be measured via LC/MS-MS. Aflatoxin analysis will be performed using high-performance liquid chromatography (HPLC), whilst pesticide residues and methanol concentrations will be assessed using a gas chromatography (GC) method equipped with computer-integrated software. This research will be undertaken in three phases. The first phase is collecting food and beverage samples (at least 30 food samples suspected of being chemically contaminated) from selected districts and assessing the toxic substances. The second phase relies on the results of the first phase; for severely contaminated foods, the sources of contamination and factors leading to the presence of chemical toxicants will be investigated. Finally, optimal processing will be investigated to remove or decrease toxic chemicals. The assessment of chemical contaminants in local foods and beverages is important as consumers become more conscious of their health and well-being. Therefore, this research aims to provide insight into the existence, concentrations, and possible health hazards associated with chemical contaminants in foods and beverages that are produced locally. It also makes actionable suggestions for resolving this pressing problem.

Executive Summary Concerns over chemical contaminants and toxins in local foods and beverages have been raised recently. These days, chronic illness is more common, and toxicants and other contaminants found in food and drink have been linked to many documented fatalities. The chemical toxicants that will be analyzed in this study include acrylamide (a processing toxicant arising from deep roasting of food samples), aflatoxin B1 (a poisonous chemical discharged by mold and fungi), pesticide residues (resulting from pesticide application to cereal, vegetable, and fruits), and methanol (a chemical toxicant produced by spontaneous fermentation of local alcoholic beverages). The acrylamide content of the food samples will be measured via LC/MS-MS. Aflatoxin analysis will be performed using high-performance liquid chromatography (HPLC), whilst pesticide residues and methanol concentrations will be assessed using a gas chromatography (GC) method equipped with computer-integrated software. This research will be undertaken in three phases. The first phase is collecting food and beverage samples (at least 30 food samples suspected of being chemically contaminated) from selected districts and assessing the toxic substances. The second phase relies on the results of the first phase; for severely contaminated foods, the sources of contamination and factors leading to the presence of chemical toxicants will be investigated. Finally, optimal processing will be investigated to remove or decrease toxic chemicals. The assessment of chemical contaminants in local foods and beverages is important as consumers become more conscious of their health and well-being. Therefore, this research aims to provide insight into the existence, concentrations, and possible health hazards associated with chemical contaminants in foods and beverages that are produced locally. It also makes actionable suggestions for resolving this pressing problem.

This study systematically assessed the concentrations of selected metals and the proximate composition of milk samples collected from six locations: Agerie Milk Cooperative, Andassa Livestock Research Center, Tekelehymanot Monastery, the College of Agriculture and Environmental Sciences, Bahir Dar Dairy Cooperative, and households in Keble-7, Bahir Dar city. Proximate composition, including moisture, ash, protein, and fat, was determined using the Kjeldahl digestion and Gerber methods, while metal analysis was performed using the Inductively Coupled Plasma Optical Emission Spectroscopy technique. The findings revealed significant variations (P

Journalists usually struggle to maintain private affairs with their professional responsibili-ties while practising journalism. This article scrutinizes the interplay between journal-ists’ professional and individual exposures and its impacts on the culture of journalismpractice in the Ethiopian state media perspective of Amhara Media Corporation (AMC).Qualitative research method, along with in-depth interviews and document analysis,was used to collect data. Semi-structured questions were forwarded to twelve purpo-sively selected journalists working in AMC. Individual-level analysis of the Hierarchy ofInfluences Model (HIM) and Individual Level of Branding were applied as theoreticaltemplates. Findings reveal that journalists’ journalistic contents are exposed to numer-ous occupational-level perspectives. Individual backgrounds and professional dilemmasjournalists face are the dominant challenges while practising professional journalism.Journalists’ academic qualifications and upbringing do have strong linkages with theirculture of journalism practice. The interface between sensitive reporting on politics, ethnic-ity, religion and professionalism is seen resulted in eroding journalistic integrity and creat-ing professional dilemmas among journalists in Ethiopia. It is recommended that mediaorganizations have comprehensible working guidelines and editorial policies to alleviate
he blurred lines between individual exposures and the professionalism of journalists inEthiopia.Keywords: hierarchy of influences model, ideological branding, individual-level analysis,journalist background, sensitive reporting, political stance, professional dilemma

Background: Cisplatin-based chemotherapy regimen associated nephrotoxicity is a significantadverse effect that restricts the standard dose of cisplatin by impairing renal function. There is alack of data on cisplatin-based chemotherapy-induced nephrotoxicity (CIN) in Ethiopian patientswith gynecological cancer. This study evaluated the factors associated with CIN and its impact onthe survival status of patients with gynecological cancer at Northwest Ethiopia oncology centers.Methods: This institutional-based retrospective cohort study included patients with gynecologicalcancer who received cisplatin-based chemotherapy between 2020 and 2021 at NorthwestEthiopia oncology centers. CIN was evaluated using the Common Terminology Criteria forAdverse Events (CTCAE) version 4 criteria and Kidney Disease Improving Global Outcomes(KDIGO) Guideline. A logistic regression model was used to identify the factors associated withCIN. The Cox proportional hazards regression model was used to determine the impact of CINonpatients survival. The cutoff point was a P value of < 0.05 for declaring statistical significance.Results: A total of 394 patients with gynecological cancer were included in the final analysis. Theincidence of CIN was 27.9 % (95 % CI 23.4,32.7). Old age (≥60 years) [adjusted odds ratio(AOR)=1.7,95 % confidence interval (CI) (1.1–2.9); P=0.039],low serum albumin (50 mg/m2) [AOR=2.6,95% CI (1.4–4.7), P=0.002]were significantly associated with CIN.CIN[(adjusted hazard ratio(AHR)=3.2,95 % CI (2.7–9.5), P=0.004]and cisplatin dose reduction [AHR=2.7,95 % CI(1.7–4.3) P=0.021] were significant factors of death among patients with gynecological cancer.Conclusion: More than a quarter of patients receiving cisplatin-based chemotherapy developedCIN, which negatively affected their survival. This study recommends that prescribers pay specialattention to patients with older age, lower serum albumin levels, and high-dose cisplatin toimprove renal function and survival. Cisplatin-based chemotherapy-induced nephrotoxicitysignificantly affects the survival of gynecological cancer patients.
Keywords: Gynecological cancer, Cisplatin, Nephrotoxicity, Factors, Impact, Ethiopia

This paper presents a novel approach to modeling and controlling a solar photovoltaic conversionsystem(SPCS) that operates under real-time weather conditions. The primary contribution is theintroduction of an uncertain model, which has not been published before, simulating the SPCS’sactual functioning. The proposed robust control strategy involves two stages: first, modifying thestandard Perturb and Observe (P&O) algorithm to generate an optimal reference voltage usingreal-time measurements of temperature, solar irradiance, and wind speed. This modification leadsto determining and linearizing the nonlinear current-voltage (I-V) characteristics of the photovoltaic(PV) array near standard test conditions (STC), resulting in an uncertain equivalent resistance used tosynthesize an overall model. In the second stage, a robust fixed-order H∞ controller is designed basedon this uncertain model, with frequency-domain specifications framed as a weighted-mixed sensitivityproblem. The optimal solution provides the controller parameters, ensuring good reference trackingdynamics, noise suppression, and attenuation of model uncertainties. Performance assessments atSTC compare the standard and robust P&O-MPPT strategies, demonstrating the proposed method’ssuperiority in performance and robustness, especially under sudden meteorological changes andvarying loads. Experiment results confirm the new control strategy’s effectiveness over the standardapproach.

Background: Diagnosing pulmonary tuberculosis (pTB) in children is challenging due to the difficulties in acquiring respiratory specimens, which unspecific and paucibacillary disease presentation, and the lack of sensitive diagnostic assays with non-invasive sample collection methods. As a result, millions of children around the world get tuberculosis (TB) each year, which is a leading cause of morbidity and mortality.
Objective: The aim of this study was to assess the diagnostic accuracy of Stool and Respiratory Sample-based Genexpert MTB/RIF assay from presumptive TB among children in Northwest, Ethiopia.
Methods and Materials: Hospital based cross-sectional with diagnostic accuracy study was conducted on consecutively recruited presumptive TB children. Data were collected by sem-structured questionnaires. Single respiratory (5ml) and 3g stool specimen were collected Lowenstein Jensen (LJ) and Xpert assay. Laboratory SOPs were strictly followed to assure the quality of whole procedures. The diagnostic accuracy of stool Xpert was evaluated against respiratory specimen Xpert, culture and composite reference standards (CRS). Sensitivity, specificity, and predictive values for the stool Xpert assay were calculated with a 95% confidence interval (95% CI) with MedCal statistical software. Data were entered in EPIData V4.2 and exported to SPSS 25 for further analysis.
Results: A total of 557 children were recruited; 510 of whom had complete microbiological results. Overall, pTB was diagnosed in 52/510 (10.2%) of the children with presumptive TB. Of these, only four had microbiologically unconfirmed pTB, were clinically diagnosed with positive response to anti-TB and the remaining 48 were microbiologically confirmed (Positive Xeprt and LJ culture). Stool specimen Xpert had sensitivity of 93.8 %( 95%CI: 82.8-98.6) and specificity of 99.8% (95%CI: 98.7–100) compared to culture; however, the sensitivity of stool was 88.5% (72-95.6) and specificity 100% (99.2-100) when compared to CRS. The Xpert on respiratory specimen had sensitivity and specificity of 95.8 % (85.8– 99.5) and 99.8% (98.7–100) to culture and 92.3 %( 81.4-97.9) and 100% (99.2-100) compared to CRS.
Conclusion: The sensitivity and specificity of Xpert assay for stool specimen is almost similar to that of respiratory specimen. Stool specimen is a highly promising alternative specimen in the diagnosis of pTB in children when respiratory specimen is impossible.


Key words: Diagnostic accuracy, pulmonary tuberculosis, Xpert MTB/RIF, Stool, Children

Recent advances in electrochemistry and electrode surface modification highlight the potential of transitionmetal coordination compounds as effective modifiers. This study presents sodium tetraresorcinolatocuprate(II)(Na₂[Cu(HR)₄]), a newly synthesized compound characterized using UV–Vis, FT-IR spectroscopy, ICP OES, andmelting point analysis. A poly(Na₂[Cu(HR)₄])/GCE was fabricated via potentiodynamic techniques, with cyclicvoltammetry and electrochemical impedance spectroscopy confirming the formation of a polymer film thatenhanced the electrode’s active area and electrocatalytic properties. The developed poly(Na₂[Cu(HR)₄])/GCEwas applied for determination of ciprofloxacin (CPF), an antibiotic prone to resistance issues, that requiresreliable monitoring in pharmaceutical and biological samples. The poly(Na₂[Cu(HR)₄]) modifier significantlyimproved CPF detection by reducing its oxidation potential and increasing current response by eightfoldcompared to unmodified electrodes, suggesting the modifier’s catalytic role in CPF oxidation. Differential pulsevoltammetry (DPV) showed a linear CPF response over concentrations of 1.0 × 10 8 to 4.0 × 10 4 M, withdetection and quantification limits of 2.0 nM and 6.8 nM, respectively. Analysis of commercial CPF brandsshowed 98.05–100.00 % accuracy, while spike recovery rates (99.25–100.40 %) and low interference errors(