Abstract: Diarrheagenic Escherichia coli (DEC) are the leading cause of infectious diarrhea and posea significant global, regional, and national burden of disease. This study aimed to investigate theprevalence of six DEC pathotypes in children with diarrhea and determine their antibiotic resistancepatterns. Samples from 107 diarrheagenic children were collected and processed for Escherichiacoli (E. coli). Single-plex PCR was used to detect target virulence genes as well as characterize andcategorize DEC pathotypes. Antibiotic resistance patterns were determined by the Kirby–Bauerdisk diffusion method. E. coli was detected in 79 diarrheal stool samples, accounting for 73.8% ofthe samples collected. Additionally, 49.4% (39 out of 79) of the isolates harbored various typicalvirulence factors. Results revealed six pathotypes of virulence: enterotoxigenic E. coli (ETEC) (53.8%),enteropathogenic E. coli (EPEC) (12.8%), enteroaggregative E. coli (EAEC) (10.3%), Heteropathotypes(7.8%), Shiga toxin-producing E. coli (STEC), and enterohemorrhagic E. coli (EHEC) (7.7% each).The isolates exhibited high antibiotic resistance against trimethoprim/sulfamethoxazole (82.1%),amoxicillin (79.5%), ampicillin (74.4%), gentamicin (69.2%), and streptomycin (64.1%). An overalloccurrence of 84.6% of multiple-drug resistance was observed in the isolates, with resistance rangingfrom three to four antibiotic classes. Our findings revealed a high level of pathogenic E. coli that werehighly resistant to multiple categories of antibiotics among children in the Awi zone. These findingshighlight the potential role of pathogenic E. coli in childhood diarrhea in tropical low-resourcesettings and underscore the need for continued research on the characteristics of pathogenic andantibiotic-resistant strains.Keywords: children; diarrheagenic Escherichia coli; resistance; virulent genes; Awi zone

Background: Developmental delay is a group of disorders that cause commondeficits of adaptive and intellectual function in children. It happens when achild fails to achieve one aspect of developmental skills. Limited informationis available regarding the prevalence of developmental delay among childrenaged 12–59 months in the study area. Therefore, this study aimed to assessthe prevalence of developmental delay and its associated factors among thispopulation.Methods: A community-based cross-sectional study was conducted inDembecha district among 702 children aged 12–59 months. Data were gatheredthrough face-to-face interviews, and by taking anthropometric measurementsusing a pretested structured questionnaire. Data were entered into Epi Dataversion 4.2 software and exported into Statistical Package for Social Science(SPSS) version 25 software for analysis. The WHO Anthro software was used toanalyze anthropometric-related data. Bivariable and multivariable binary logisticregression analyses were done to identify factors associated with developmentaldelay. The odds ratio with a 95% Confidence Interval (CI) was estimated todetermine the strength of the association.Results: The prevalence of developmental delay among children was 26.7%(95% CI: 23.5, 30.2). Toddler child age (AOR = 2.60; 95% CI: 1.42, 4.87), lowbirth weight (LBW; AOR =4.90; 95% CI: 2.14, 11.48), cesarean section mode ofdelivery (AOR = 8.60; 95% CI: 3.93, 18.65), preterm delivery (AOR = 2.5; 95% CI:1.28, 4.74), early initiation of complementary feeding (AOR = 8.40; 95% CI: 3.61,19.63), stunting (AOR = 2.90; 95% CI: 1.67, 5.22) inadequate meal frequency(AOR = 3.20; 95% CI: 1.74, 5.94), and inadequate dietary diversity (AOR = 3.10;95% CI: 1.68, 5.85) were significantly associated with child developmental delay.Conclusion: The prevalence of developmental delay among children was highin Dembecha district compared to the global prevalence. Child developmentaldelay was associated with toddler child age, LBW, cesarean section mode of

This research has been designed to explore some choreographic matters of selected Amharic Music, and it has employed stylistics approach in association with the musical functions or thematic purposes related to visual narrative inquiry.
The rationale behind the research project was related to the discussion of some choreographic maters of this study in relation to theme, creativity and deviation related to the videos of the selected music, for such practice has been less experienced in researches before. This is so, for people in most of the time perceive the choreographic matters or form related issues of music and the thematic function which could be transferred through the videos as independent concerns. However, form and content of a certain artistic production are the two sides of a coin which could not be investigated and understood independently; this is so, for, it is obvious that what is made on the form is all about the content of any artistic production and vice-versa. This was made in this study with the discussion of the concept, choreographic matters of some selected Amharic Music made on the presupposed themes advocated by the videos in relation to the range of creativity and deviation.
Therefore, the intention of the current study was to deal with the exploration of choreographic matters as reflected in the musical videos in relation to creativity and deviation made to convey thematic matters of the videos, for these two artistic concepts (creativity and deviation) are the inevitable techniques of music as one genre of fine art. The study has been concluded with the following demonstration.
On top of their own peculiarities, all the videos are similar in their disclosure of artistic creativities experienced both in content and form levels. This creativity extends the range of experiencing artistic deviations. At least all the selected videos commonly share the ideas in dealing with the videos potential of keeping traditional dance movements, the range of improvisations and expressiveness inculcated in line with modernizing the dances in the videos and the intentional and unintentional global influences and hybridizations.

Background: Cisplatin-based chemotherapy regimen associated nephrotoxicity is a significantadverse effect that restricts the standard dose of cisplatin by impairing renal function. There is alack of data on cisplatin-based chemotherapy-induced nephrotoxicity (CIN) in Ethiopian patientswith gynecological cancer. This study evaluated the factors associated with CIN and its impact onthe survival status of patients with gynecological cancer at Northwest Ethiopia oncology centers.Methods: This institutional-based retrospective cohort study included patients with gynecologicalcancer who received cisplatin-based chemotherapy between 2020 and 2021 at NorthwestEthiopia oncology centers. CIN was evaluated using the Common Terminology Criteria forAdverse Events (CTCAE) version 4 criteria and Kidney Disease Improving Global Outcomes(KDIGO) Guideline. A logistic regression model was used to identify the factors associated withCIN. The Cox proportional hazards regression model was used to determine the impact of CINonpatients survival. The cutoff point was a P value of < 0.05 for declaring statistical significance.Results: A total of 394 patients with gynecological cancer were included in the final analysis. Theincidence of CIN was 27.9 % (95 % CI 23.4,32.7). Old age (≥60 years) [adjusted odds ratio(AOR)=1.7,95 % confidence interval (CI) (1.1–2.9); P=0.039],low serum albumin (50 mg/m2) [AOR=2.6,95% CI (1.4–4.7), P=0.002]were significantly associated with CIN.CIN[(adjusted hazard ratio(AHR)=3.2,95 % CI (2.7–9.5), P=0.004]and cisplatin dose reduction [AHR=2.7,95 % CI(1.7–4.3) P=0.021] were significant factors of death among patients with gynecological cancer.Conclusion: More than a quarter of patients receiving cisplatin-based chemotherapy developedCIN, which negatively affected their survival. This study recommends that prescribers pay specialattention to patients with older age, lower serum albumin levels, and high-dose cisplatin toimprove renal function and survival. Cisplatin-based chemotherapy-induced nephrotoxicitysignificantly affects the survival of gynecological cancer patients.
Keywords: Gynecological cancer, Cisplatin, Nephrotoxicity, Factors, Impact, Ethiopia

This study aims and documents the clinical and laboratory diagnosis of bovine dermatophilosis, caused by Dermatophiluscongolensis that causes exudation and matting of hairs and wools with the formation of crusts and scab. An adult local breed bullwith a history of reduced appetite, pruritus, dirty scabs and crusts as initial lesion coalesce on its different body parts was presentedto Debre Markos multipurpose veterinary clinic. The rectal temperature and other vital parameters were within the normalrange. The clinical signs observed were exudative dermatitis forming crusts and scabs, pruritus, matted hair like a paintbrushand keratinized material creating wart-like lesions that were widely distributed in different body parts. Few ticks were observedon the skin of the bull suspected as vector of the disease. Culture of skin scraps on blood agar showed small, grayish-white raisedgranular and hemolytic colonies. Staining of skin scraps by Giemsa and Gram’s stain and cultured colony by Gram’s stain indicatedthe characteristics of Dermatophilus congolensis, etiology of dermatophilosis. Other laboratory tests also showed the characteristicsof D. congolensis. The case was treated by penstrep and ivermectin parentally and iodine tincture topically, and the bull showedprogressive clinical improvement and complete recovery within 2 months. In conclusion, dermatophilosis is an economicallyimportant skin disease, highly prevalent in Ethiopia, and needs early detection and treatment by penstrep intramuscularly andivermectine subcutaneously with iodine tincture topically in line with proper husbandry practices to control the losses.
Keywords: Dermatophilus congolensis; bull; clinical diagnosis; dermatophilosis; skin.

IntroductionCancer is a leading cause of global morbidity and mortality, significantly impairing patients’quality of life (QoL). Integrated Palliative Care (IPC) has been proposed as a holisticapproach to enhance quality of life by addressing patients’ physical, emotional, and psy-chosocial needs. While some studies suggest Integrated Palliative Care improves qualityof life more than standard care, the evidence remains inconclusive. This systematic reviewand meta-analysis aim to evaluate the comparative impact of Integrated Palliative Careversus standard care on the quality of life in cancer patients.MethodsA comprehensive search of databases including PubMed, Cochrane Library, and Embase wasconducted. We selected randomized controlled trials (RCTs) comparing Integrated Palliative Careand standard care for cancer patients, focusing on the quality of life as measured by validatedtools such as the EORTC QLQ-C30 and FACT-G. Data were pooled using a random-effectsmodel to account for study heterogeneity. Subgroup and sensitivity analyses were also performed.ResultsNine randomized controlled trials involving 1,794 patients met the inclusion criteria.Meta-analysis showed that Integrated Palliative Care significantly improved quality oflife compared to standard care (SMD = 3.25; 95% CI: 1.20–5.30; p < 0.001). Studiesconducted in Asia showed the highest standardized mean difference (SMD = 6.15; 95%CI: 3.07–9.23; p < 0.001), followed closely by studies from Africa (SMD = 6.0; 95% CI:5.13–6.87; p < 0.001), compared to those from other regions. Similarly, research focusingon lung cancer patients showed the greatest standardized mean difference of (SMD =6.15; 95% CI: 3.07–9.23; p < 0.001) relative to other cancer types. Furthermore, studies
involving newly diagnosed cancer patients recorded the highest standardized mean differ-ence of (SMD = 5.69; 95% CI: 4.57–6.80; p < 0.001).ConclusionIntegrated Palliative Care significantly enhances the quality of life in cancer patients comparedto standard care. These findings support integrating Integrated Palliative Care into oncologypractices to provide comprehensive, patient-centered care that addresses both physical andemotional needs. Further research should explore long-term benefits across diverse populations.

This study investigates the performance of hemispherical solar stills (HSS) enhanced with date kernelsand olive kernels as heat storage materials to improve water distillation efficiency. By utilizing thesenatural and sustainable materials, the research highlights an alternative to synthetic options. Rigorousexperimentation and detailed analysis under identical conditions reveal that both kernels significantlyimprove heat retention and water production rates. The HSS with date kernels (HSSDK) achieved adaily water productivity of 6.66 kg/m2 day, representing an efficiency increase of 10.87%, while theHSS with olive kernels (HSSOK) produced 8.00 kg/m2 day, enhancing efficiency by 13.54%. The cost perm3 of distilled water for HSSDK is approximately USD 4.65, while HSSOK costs USD 3.89, comparedto USD 7.83 for the conventional CHSS system. These results demonstrate that the inclusion of heatstorage materials has significantly reduced the cost of water production, with reductions of about 40%for HSSDK and 50% for HSSOK compared to the conventional system. These results are attributedto the high thermal conductivity and specific heat capacities of the kernels, enabling effective heatstorage and gradual release. This study demonstrates the potential of agricultural by-products ascost-effective and sustainable solutions for solar water distillation. Further research is recommendedto optimize the quantities and configurations of these materials, as well as to explore their integrationwith other renewable energy systems to enhance overall efficiency and sustainability.Keywords: Hemispherical solar still, Date kernels, Olive kernels, Heat storage materials, Distillation efficiency

This study examines the commitment and compliance of two key rebel groups in the Ethiopian Civil War—theTigray People’s Liberation Front and the Oromo Liberation Front—to international human rights norms, utilizingthe Jo and Bryant framework of human rights commitment and compliance for non-state actors as an analyticaltool. A systematic secondary document analysis was conducted, with data sourced from national and interna-tional media outlets, as well as reports from humanitarian organizations. The Tigray People’s Liberation Front ischaracterized by a more centralized and disciplined organizational structure, which has facilitated greateraccountability for its actions. In contrast, the Oromo Liberation Front has faced significant internal fragmentationand weak command, complicating the attribution of responsibility. Despite these organizational differences, bothgroups share a record of serious human rights violations, including the mistreatment of prisoners of war, masscivilian killings, forced displacements, and the use of child soldiers. While neither group fully adheres to humanrights standards, the Tigray People’s Liberation Front has demonstrated a relatively greater capacity to facilitatehumanitarian aid, although this aid is frequently diverted for military purposes, undermining its intendedsupport for civilians. This diversion reflects a troubling pattern of aid misappropriation that compromises theeffectiveness of humanitarian efforts in conflict zones. Conversely, the Oromo Liberation Front’s lack of coop-eration with humanitarian agencies further exacerbates the suffering of affected populations, underscoring theneed for both groups to reassess their commitment to humanitarian principles and the protection of civilianrights. The study calls for international actors to exert pressure on both groups to ensure compliance with at leasta minimum standard of human rights norms.
Keywords: Ethiopia, Civil war, Human rights compliance, Rebel groups

The purpose of the study was to examine the association between depression and substance abuse and to assess theirprevalence and associated factors. A cross-sectional design was employed. To collect data for the present study, 2 scales (Beckdepression inventory and Alcohol, Smoking, and Substance Involvement screening Test [ASSIST]) was administered to students.Two hundred fifty seven Addis Ababa Institute of Technology final year regular undergraduate students were participated. Theresults revealed that a high correlation was found between depression and substance abuse. The prevalence of depression is27.2%. Similarly, the prevalence of alcohol abuse, khat abuse, cigarette abuse and cannabis abuse are 25.5%, 17.7%, 9.5%, and3.3% respectively. Hence, the overall substance abuse prevalence is 14%. Alcohol is most abused drug followed by khat abuse.Cigarette and cannabis abuse take the 3rd and 4th rank respectively. Multivariate test of significance reveals that gender, religionand the interaction of gender with religion, residence, and ethnicity had an effect on the two combined dependent measures.Females are more depressed than males. In turn, males are more substance abusers than females. The researchers suggestedthat the university to establish its own substance abuse prevention and treatment working center which is open for psychologists,therapist and other health workers.Abbreviations: AAIT = Addis Ababa Institute of Technology, ASSIST = Alcohol, Smoking, and Substance Involvement ScreeningTest, BDI = Beck Depression Inventory, MANOVA = Multiple Analysis of Variance, WHO = World Health Organization.Keywords: alcohol, depression, khat, substance abuse, university students

Background Microcephaly and macrocephaly, which are abnormal congenital markers, are associated withdevelopmental and neurologic deficits. Hence, there is a medically imperative need to conduct ultrasound imagingearly on. However, resource-limited countries such as Ethiopia are confronted with inadequacies such that access totrained personnel and diagnostic machines inhibits the exact and continuous diagnosis from being met.Objective This study aims to develop a fetal head abnormality detection model from ultrasound images via deeplearning.Methods Data were collected from three Ethiopian healthcare facilities to increase model generalizability.The recruitment period for this study started on November 9, 2024, and ended on November 30, 2024. Severalpreprocessing techniques have been performed, such as augmentation, noise reduction, and normalization.SegNet, UNet, FCN, MobileNetV2, and EfficientNet-B0 were applied to segment and measure fetal head structuresusing ultrasound images. The measurements were classified as microcephaly, macrocephaly, or normal using WHOguidelines for gestational age, and then the model performance was compared with that of existing industry experts.The metrics used for evaluation included accuracy, precision, recall, the F1 score, and the Dice coefficient.Results This study was able to demonstrate the feasibility of using SegNet for automatic segmentation,measurement of abnormalities of the fetal head, and classification of macrocephaly and microcephaly, with anaccuracy of 98% and a Dice coefficient of 0.97. Compared with industry experts, the model achieved accuracies of92.5% and 91.2% for the BPD and HC measurements, respectively.Conclusion Deep learning models can enhance prenatal diagnosis workflows, especially in resource-constrainedsettings. Future work needs to be done on optimizing model performance, trying complex models, and expandingdatasets to improve generalizability. If these technologies are adopted, they can be used in prenatal care delivery.Clinical trial number Not applicable.Keywords Microcephaly, Macrocephaly, Congenital abnormality, HC, BPD