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Debre Markos University offers a Browse by Title feature within its Institutional Research Repository System that enables users to easily find and access academic research outputs by their titles. This feature organizes theses, dissertations, and other scholarly works alphabetically or by keyword in the title, allowing researchers, students, and the community to quickly locate specific documents when they know all or part of a title. By focusing on titles, users can efficiently explore the repository's collection and discover relevant research materials without needing to search by author or department.

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Factors Associated with the Intention and Practice of Blood Donation among Urban Adults in East Gojjam Zone, Northwest Ethiopia
Research Paper
Nigusie Gashaye (Assistance Professor. in Biostatistics, Department of Statistics, DMU) - PIMisganaw Mekonnen (M.Sc. in Biostatistics, Department of Statistics, DMU) - COIMihretie Gedfew (Assistant Professor in Adult Health Nursing, Department of Nursing, DMU) - COIAwoke Fetahi (M.Sc. in Biostatistics, Department of Statistics, DMU) - COIMetadel Azeze (M.Sc. in Biostatistics, Department of Statistics, DMU) - COIFetene Getnet (B.Sc. in Statistics, Department of Statistics, DMU) - COI Submitted: Oct 30, 2025
Natural & Computational Sciences Statistics
Abstract Preview:
ABSTRACT Background: Blood donation is vital for saving lives, yet Ethiopia faces chronic shortages. Bridging the gap between willingness and actual donation is essential for sustaining blood supplies. This study examined socio-demographic, psychological, and contextual factors influencing blood donation intention and practice in East Gojjam Zone. Methods: A community-based cross-sectional survey of 1,332 urban adults who met inclusion criteria was conducted using multistage cluster sampling. Data were collected via a structured, pre-tested questionnaire. Descriptive statistics summarized donation patterns, while binary logistic and Zero-Inflated Negative Binomial regressions identified predictors of donation intention and frequency, respectively. Structural Equation Modeling (SEM) examined associations among socio-demographic characteristics, psychological factors, donation intention, practice, and behavior. Results: Although 74.8% (95% CI: 72.5–77.1) expressed willingness to donate, only 28.8% (95% CI: 26.4–31.2) had ever donated, and 20.7% (95% CI: 18.5–22.9) had donated in the past two years. Male gender, younger age, higher education, and employment in health or education sectors positively predicted intention and practice. Psychological factors—including self-efficacy (β = 0.53), positive attitudes (β = 0.46), knowledge (β = 0.38), altruism, and social influence (β = 0.28)—were strongly associated with donation. SEM confirmed that intention strongly predicted actual donation (β = 0.62). Barriers included fear of needles, health concerns, and limited awareness. Conclusions: Despite high willingness, actual donation remains low. Multi-sectoral, culturally sensitive strategies—addressing fears, improving knowledge, leveraging social influence, and enhancing accessibility—are critical, especially for women, older adults, and less-educated individuals, to build a resilient, community-driven blood supply. Keywords: Blood donation, intention, practice, socio-demographic factors, psychological determinants, Ethiopia, Structural Equation Modeling
Full Abstract:
ABSTRACT Background: Blood donation is vital for saving lives, yet Ethiopia faces chronic shortages. Bridging the gap between willingness and actual donation is essential for sustaining blood supplies. This study examined socio-demographic, psychological, and contextual factors influencing blood donation intention and practice in East Gojjam Zone. Methods: A community-based cross-sectional survey of 1,332 urban adults who met inclusion criteria was conducted using multistage cluster sampling. Data were collected via a structured, pre-tested questionnaire. Descriptive statistics summarized donation patterns, while binary logistic and Zero-Inflated Negative Binomial regressions identified predictors of donation intention and frequency, respectively. Structural Equation Modeling (SEM) examined associations among socio-demographic characteristics, psychological factors, donation intention, practice, and behavior. Results: Although 74.8% (95% CI: 72.5–77.1) expressed willingness to donate, only 28.8% (95% CI: 26.4–31.2) had ever donated, and 20.7% (95% CI: 18.5–22.9) had donated in the past two years. Male gender, younger age, higher education, and employment in health or education sectors positively predicted intention and practice. Psychological factors—including self-efficacy (β = 0.53), positive attitudes (β = 0.46), knowledge (β = 0.38), altruism, and social influence (β = 0.28)—were strongly associated with donation. SEM confirmed that intention strongly predicted actual donation (β = 0.62). Barriers included fear of needles, health concerns, and limited awareness. Conclusions: Despite high willingness, actual donation remains low. Multi-sectoral, culturally sensitive strategies—addressing fears, improving knowledge, leveraging social influence, and enhancing accessibility—are critical, especially for women, older adults, and less-educated individuals, to build a resilient, community-driven blood supply. Keywords: Blood donation, intention, practice, socio-demographic factors, psychological determinants, Ethiopia, Structural Equation Modeling
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Geéz Grammar Error Handling Using Neural Machine Translation Approach
Journal Article
Eshete Derb Emiru, Desalegn Mamo Wendyifraw Submitted: Mar 11, 2025
Institute of Technology Information Technology
Abstract Preview:
The goal of natural language processing (NLP), which has recently gained popularity, is to improve the ca-pacity of computers to comprehend and interact with human language. Consequently, to converse usingnatural language, it is crucial that spoken language be grammatically correct, especially for Geéz language.Geéz language sentences must follow certain norms of agreement in terms of number, person, gender, tense,and other factors to be considered grammatically correct. If the input sentence in Geéz language is improper,then it can have problems with subject-verb agreement, object-verb agreement, adjective-noun agreement,and adverb-verb agreement. The goal of the proposed work is to provide a neural machine translation ap-proach for detecting and correcting grammar errors in Geéz sentences. We have prepared manually 11,490Geéz parallel corpuses (Geéz language grammatically incorrect and grammatically correct sentences). Afterwe have prepared a parallel Geéz sentence, we have used normalization, tokenization, padding, and one hotencoding as preprocesses. We have used two deep learning algorithms, including a bidirectional long short-term memory encoder-decoder and a long short-term memory encoder-decoder, for training the proposedmodel. Keras and TensorFlow were used for importing the required libraries, and we used the Python 3.7 en-vironment for implementation. Two test cases are used for the evaluation technique. The first one is for thelong short-term memory encoder-decoder model, and the second one is for the bidirectional long short-termmemory encoder-decoder model. Finally, the bidirectional long short-term memory encoder-decoder modelachieved best results with an accuracy of 82%, recall of 82%, precision of 85%, and F1-measure of 83% withbalanced error type classes.CCS Concepts: • Computing methodologies → Machine translation;Additional Key Words and Phrases: NMT, GSD, GGEH, NLP, DL, LSTM, BILSTM
Full Abstract:
The goal of natural language processing (NLP), which has recently gained popularity, is to improve the ca-pacity of computers to comprehend and interact with human language. Consequently, to converse usingnatural language, it is crucial that spoken language be grammatically correct, especially for Geéz language.Geéz language sentences must follow certain norms of agreement in terms of number, person, gender, tense,and other factors to be considered grammatically correct. If the input sentence in Geéz language is improper,then it can have problems with subject-verb agreement, object-verb agreement, adjective-noun agreement,and adverb-verb agreement. The goal of the proposed work is to provide a neural machine translation ap-proach for detecting and correcting grammar errors in Geéz sentences. We have prepared manually 11,490Geéz parallel corpuses (Geéz language grammatically incorrect and grammatically correct sentences). Afterwe have prepared a parallel Geéz sentence, we have used normalization, tokenization, padding, and one hotencoding as preprocesses. We have used two deep learning algorithms, including a bidirectional long short-term memory encoder-decoder and a long short-term memory encoder-decoder, for training the proposedmodel. Keras and TensorFlow were used for importing the required libraries, and we used the Python 3.7 en-vironment for implementation. Two test cases are used for the evaluation technique. The first one is for thelong short-term memory encoder-decoder model, and the second one is for the bidirectional long short-termmemory encoder-decoder model. Finally, the bidirectional long short-term memory encoder-decoder modelachieved best results with an accuracy of 82%, recall of 82%, precision of 85%, and F1-measure of 83% withbalanced error type classes.CCS Concepts: • Computing methodologies → Machine translation;Additional Key Words and Phrases: NMT, GSD, GGEH, NLP, DL, LSTM, BILSTM
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Genotype by environment interaction and yield stability analysis of bread wheat (Triticum aestivum L.) varieties in East Gojjam Zone, Northwest Ethiopia
Journal Article
Alemnesh Eskezia *, Habtamu Kefale , Mekonen Asrat Submitted: Jun 20, 2025
Agriculture and Natural resources Plant Science
Abstract Preview:
Bread wheat (Triticum aestivum L.) is vital for over a third of the global population but facessignificant production challenges due to limited adaptable varieties, poor management practices,and environmental factors. New wheat varieties often fail in unfamiliar environments, leading tocrop loss. To address this issue, a study was conducted to evaluate the adaptability, performance,and yield stability of recently released high-performing wheat varieties over two years (2020/2021 and 2021/2022) in four districts of the East Gujjar Zone: Machakel, Debre Elias, Gozamin,and Baso-Liben. The trials were set up using a randomized complete block design (RCBD) withthree replications, and data were collected on the main traits such as days to heading, maturity,plant height, tiller number, spike length, spikelet’s per spike, biomass, and grain yield. AMMI andGEE biplot analysis were used to study genotype by environmental interaction. The combinedanalysis of variance for grain yield showed highly significant effects (P < 0.001) due to genotype(4.98 %), environment (66.83 %), and genotype × environment interaction (31.96 %). Grainyield varied across the environments, ranging from 3.72 t ha 1in Baso-Liben to 3.11 t ha 1 inMachakel. Among the genotypes, Ogolcho had the highest mean yield (4.55 t ha 1), whereasWane had the lowest (2.70 t ha 1). Genotype-by-environment interaction biplot analysis groupedthe eight test environments and six genotypes into two mega-environments and three genotypegroups. Wane, Lemu, and Ogolcho were the stable genotypes. This analysis identified the mostfavorable districts for wheat production and highlighted Ogolcho as the most productive wheatvariety in the study area. The results suggest that farmers in these districts should adopt Ogolchoto enhance wheat yield and increase their income.
Keywords: AMMI, GGE, GIE, PCA, Stability, Wheat
Full Abstract:
Bread wheat (Triticum aestivum L.) is vital for over a third of the global population but facessignificant production challenges due to limited adaptable varieties, poor management practices,and environmental factors. New wheat varieties often fail in unfamiliar environments, leading tocrop loss. To address this issue, a study was conducted to evaluate the adaptability, performance,and yield stability of recently released high-performing wheat varieties over two years (2020/2021 and 2021/2022) in four districts of the East Gujjar Zone: Machakel, Debre Elias, Gozamin,and Baso-Liben. The trials were set up using a randomized complete block design (RCBD) withthree replications, and data were collected on the main traits such as days to heading, maturity,plant height, tiller number, spike length, spikelet’s per spike, biomass, and grain yield. AMMI andGEE biplot analysis were used to study genotype by environmental interaction. The combinedanalysis of variance for grain yield showed highly significant effects (P < 0.001) due to genotype(4.98 %), environment (66.83 %), and genotype × environment interaction (31.96 %). Grainyield varied across the environments, ranging from 3.72 t ha 1in Baso-Liben to 3.11 t ha 1 inMachakel. Among the genotypes, Ogolcho had the highest mean yield (4.55 t ha 1), whereasWane had the lowest (2.70 t ha 1). Genotype-by-environment interaction biplot analysis groupedthe eight test environments and six genotypes into two mega-environments and three genotypegroups. Wane, Lemu, and Ogolcho were the stable genotypes. This analysis identified the mostfavorable districts for wheat production and highlighted Ogolcho as the most productive wheatvariety in the study area. The results suggest that farmers in these districts should adopt Ogolchoto enhance wheat yield and increase their income.
Keywords: AMMI, GGE, GIE, PCA, Stability, Wheat
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Geohazard mapping and mitigations along the road corridor Gasera–Indeto, Southeast Ethiopia
Journal Article
Chalachew Tesfa Submitted: Dec 26, 2024
Institute of Technology Civil Engineering
Abstract Preview:
The study area is one of the biggest gorges in southeast Ethiopia formed by the Wabe Shebelle river. The road wasconstructed to connect Gasera to Indeto. The study aimed to map and gives some mitigation strategies forgeohazards along the road corridor in Southeast Ethiopia using a GIS with AHP & FR technique within the 3 kmbuffer zones along the road corridor. The study included field investigations and inventorying, characterizationof geological situations, assessments of the hydrogeological conditions, and identification of slope instabilityvariables. A GIS technique was used to map an LSM with the combination of two models (AHP and FR). The studyused eight factors: slope, aspect, lithology, rainfall, altitude, road proximity, river proximity, and land use/cover.The results of the study revealed that LSZ maps performed using FR and AHP were 64.5 % and 69 % and-theinventory shows high and very high LSZ respectively. Rockfalls, debris/earth slides, and rockslides arecommonly observed landslides in the area. Based on the analysis lithology (basaltic and limestone formations)showed the highest contributions for landslide in the area. Slope and aspects show the most frequent landslidehazards in >40, 30–40◦, and east, and northeast respectively. Generally, the study found that lithology, slope,and aspect were the main factors contributing to slope instability in the study area. The produced landslidesusceptibility map is very important for urban planners, agricultural studies, environmentalists, and futurelandslide hazardous prevention and mitigation strategies.
Keywords: Landslides, LSM, AHP, FR, GIS, and Southeast Ethiopia
Full Abstract:
The study area is one of the biggest gorges in southeast Ethiopia formed by the Wabe Shebelle river. The road wasconstructed to connect Gasera to Indeto. The study aimed to map and gives some mitigation strategies forgeohazards along the road corridor in Southeast Ethiopia using a GIS with AHP & FR technique within the 3 kmbuffer zones along the road corridor. The study included field investigations and inventorying, characterizationof geological situations, assessments of the hydrogeological conditions, and identification of slope instabilityvariables. A GIS technique was used to map an LSM with the combination of two models (AHP and FR). The studyused eight factors: slope, aspect, lithology, rainfall, altitude, road proximity, river proximity, and land use/cover.The results of the study revealed that LSZ maps performed using FR and AHP were 64.5 % and 69 % and-theinventory shows high and very high LSZ respectively. Rockfalls, debris/earth slides, and rockslides arecommonly observed landslides in the area. Based on the analysis lithology (basaltic and limestone formations)showed the highest contributions for landslide in the area. Slope and aspects show the most frequent landslidehazards in >40, 30–40◦, and east, and northeast respectively. Generally, the study found that lithology, slope,and aspect were the main factors contributing to slope instability in the study area. The produced landslidesusceptibility map is very important for urban planners, agricultural studies, environmentalists, and futurelandslide hazardous prevention and mitigation strategies.
Keywords: Landslides, LSM, AHP, FR, GIS, and Southeast Ethiopia
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GEʽEZ LANGUAGE REVITALIZATION STRATEGIES AND PEDAGOGICAL INTERFACES IN TEACHING INDIGENOUS VIS-À-VIS MODERN LANGUAGES: CHURCH EDUCATION AND ELEMENTARY SCHOOLS IN EAST GOJJAM
Research Paper
WONDIFRAW MIHRET (PHD IN TEFL) (PI), YESHAMBEL ALMAW (MA IN TEFL) MERGETA ANIMUT ZEMENAY (MA IN GEʽEZ AND QENE SCHOOL SCHOLAR) MERGETA ELIAS ABAT (BA IN AMHARIC AND QENE SCHOOL SCHOLAR) MENGISTU ANAGAW (PHD IN TEFL), ALEBACHEW BEYADIGIE (PHD IN APPLIED LINGUISTICS, AMHARIC) Submitted: Sep 29, 2025
Social Science and Humanities English Language and Literatures
Abstract Preview:
This study was aimed to formulate formal and non-formal Geez language revitalization strategies by specifically exploring indigenous teaching strategies, analyzing pedagogical interfaces and needs, and assessing practical off-class revitalization strategies. Exploratory Mixed methods design was utilized an experiential qualitative design complemented by descriptive assessment to explore participants' lived experiences and perceptions. The research participants were traditional church teachers teaching Geʽez integrating with religious contents in Reading, Qene, and Literature schools under Ethiopian Orthodox Tewahedo Church (EOTC) education system. Qualitative data were gathered through in-depth interview and video-supported observations, which were analyzed thematically. The study made use of Geez language professionals and practitioners from Bahir Dar and Debre Markos Universities to prioritize relevant non-formal revitalization strategies. Findings revealed that indigenous teaching uses some teacher-centered and more student-centered indigenous methods that converge and diverge with traditional and innovative pedagogies of designing, implementing and assessing Geez language. Irrespective of the delayed learning of comprehension and minimal use of functional communication, the indigenous methods church teachers used were generally more practical and effective, especially in areas such as Qene and literature schools resulting in quicker and accurate mastery of the language. The analysis of linguistic necessities and wants revealed that all skills with the emphasis of vocabulary, grammar, reading and speaking were prioritized. Integration into church schools, media, cultural events, and language nests wre selected as significant language revitalization strategies selected for both inside and outside of school settings. The study concluded that the productive indigenous methods of teaching Geʽez could complement modern language teaching pedagogies, addressing gaps in both approaches. It recommended that language professionals learn from indigenous practices and suggested that Geʽez teachers adapt these practices with modern pedagogical principles. Lastly, language program designers and educators were encouraged to reconsider effective pedagogical interfaces to address challenges in all aspects language teaching: design, implementation and assessment.
Full Abstract:
This study was aimed to formulate formal and non-formal Geez language revitalization strategies by specifically exploring indigenous teaching strategies, analyzing pedagogical interfaces and needs, and assessing practical off-class revitalization strategies. Exploratory Mixed methods design was utilized an experiential qualitative design complemented by descriptive assessment to explore participants' lived experiences and perceptions. The research participants were traditional church teachers teaching Geʽez integrating with religious contents in Reading, Qene, and Literature schools under Ethiopian Orthodox Tewahedo Church (EOTC) education system. Qualitative data were gathered through in-depth interview and video-supported observations, which were analyzed thematically. The study made use of Geez language professionals and practitioners from Bahir Dar and Debre Markos Universities to prioritize relevant non-formal revitalization strategies. Findings revealed that indigenous teaching uses some teacher-centered and more student-centered indigenous methods that converge and diverge with traditional and innovative pedagogies of designing, implementing and assessing Geez language. Irrespective of the delayed learning of comprehension and minimal use of functional communication, the indigenous methods church teachers used were generally more practical and effective, especially in areas such as Qene and literature schools resulting in quicker and accurate mastery of the language. The analysis of linguistic necessities and wants revealed that all skills with the emphasis of vocabulary, grammar, reading and speaking were prioritized. Integration into church schools, media, cultural events, and language nests wre selected as significant language revitalization strategies selected for both inside and outside of school settings. The study concluded that the productive indigenous methods of teaching Geʽez could complement modern language teaching pedagogies, addressing gaps in both approaches. It recommended that language professionals learn from indigenous practices and suggested that Geʽez teachers adapt these practices with modern pedagogical principles. Lastly, language program designers and educators were encouraged to reconsider effective pedagogical interfaces to address challenges in all aspects language teaching: design, implementation and assessment.
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GIS-Based MCDM Approach for Landslide Hazard Zonation Mapping in Eaast Gojjam, Central Ethiopia
Journal Article
Chalachew Tesfa *, Demeke Sewnet Submitted: Jun 24, 2024
Institute of Technology Civil Engineering
Abstract Preview:
Landslides are prevalent in the Ethiopian highlands, particularly in the east Gojjam zone, which is highly affectedby landslide problems. This research was carried out in the east Gojjam zone, northwestern Ethiopia. The studyarea is part of an economically important area in the country, and it is the main source of water for the GrandEthiopian Renaissance Dam (GERD). The main objective of this work was to undertake a detailed inventory ofpast landslide locations and prediction of present and future landslide hazards, as well as the preparation of alandslide zonation map in the East Gojjam zone by using the Analytical Hierarchy Process (AHP) with the GIStechnique. The parameters used for this study were slope degree, slope aspect, land use and land cover, roadproximity, rainfall, lithology, altitude, and river proximity. The various causative parameters were collected fromthe field, and suitable modifications were made to the thematic maps. Finally, the ratings for various parameterswere used as the basis to prepare the LHZ map in GIS windows. The landslide susceptibility and inventorymapping were produced in the GIS environment. The results of the study show that the main driving factors forthe landslide hazards in the area were river proximity, rainfall, and manmade activities. Validation of this LHZmap revealed that more than 80% of past landslides match within the "high hazard zone" and reasonablyaccepted the rationality of the adopted methodology. The considered parameters, as well as their evaluation ofthe production of LHZ-Map, were confirmed. The produced landslide inventory map is very important for urbanplanners, agricultural studies, environmentalists, and future landslide hazardous prevention and mitigationstrategies.
Keywords: GIS, AHP, Inventory mapping, Causative factors, Landslides
Full Abstract:
Landslides are prevalent in the Ethiopian highlands, particularly in the east Gojjam zone, which is highly affectedby landslide problems. This research was carried out in the east Gojjam zone, northwestern Ethiopia. The studyarea is part of an economically important area in the country, and it is the main source of water for the GrandEthiopian Renaissance Dam (GERD). The main objective of this work was to undertake a detailed inventory ofpast landslide locations and prediction of present and future landslide hazards, as well as the preparation of alandslide zonation map in the East Gojjam zone by using the Analytical Hierarchy Process (AHP) with the GIStechnique. The parameters used for this study were slope degree, slope aspect, land use and land cover, roadproximity, rainfall, lithology, altitude, and river proximity. The various causative parameters were collected fromthe field, and suitable modifications were made to the thematic maps. Finally, the ratings for various parameterswere used as the basis to prepare the LHZ map in GIS windows. The landslide susceptibility and inventorymapping were produced in the GIS environment. The results of the study show that the main driving factors forthe landslide hazards in the area were river proximity, rainfall, and manmade activities. Validation of this LHZmap revealed that more than 80% of past landslides match within the "high hazard zone" and reasonablyaccepted the rationality of the adopted methodology. The considered parameters, as well as their evaluation ofthe production of LHZ-Map, were confirmed. The produced landslide inventory map is very important for urbanplanners, agricultural studies, environmentalists, and future landslide hazardous prevention and mitigationstrategies.
Keywords: GIS, AHP, Inventory mapping, Causative factors, Landslides
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Green synthesis, characterization and antibacterial activities of silver nanoparticles using Sida schimperiana Hochst. ex A. Rich (Chifrig) leaves extract
Journal Article
Wendmnew Moges 1 · Yohannes Misskire Submitted: Feb 13, 2025
Agriculture and Natural resources Natural Resource Management
Abstract Preview:
The use of metal nanoparticles as antibiotics for resistant pathogens has become a current topic of research. Biosyn-thesized nanoparticles are promising drugs as antibacterial agents by inhibiting bacteria from infectious diseases. Thisstudy aimed at the synthesis and characterization of silver nanoparticles (AgNPs) from AgNO 3 solution and Sida schim-periana Hochst. ex A. Rich leaves extract. The synthesized AgNPs were characterized by Fourier Transform Infrared (FTIR),Ultraviolet–Visible (UV–Vis) and X-ray diffraction (XRD) spectroscopic techniques and evaluated for antibacterial activi-ties against Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Escherichia coliand Klebsiella Pneumonia) bacteria by the disc diffusion method. The result indicated an initial color change that wasobserved below 400 nm for the leaves extract and 429 nm for AgNPs in the UV–Vis band supporting the synthesis ofsilver nanoparticles. The FTIR peaks at 3447, 1638 and 1413 cm −1 predict the hydroxyl, carbonyl and unsaturated C–Cbonds, respectively, in the plant leaves extract. The XRD analysis showed that the synthesized AgNPs were crystalline innature and face-centered cubic (FCC) structure with an average particle size of 26.27 nm. Furthermore, the synthesizednanoparticles showed antimicrobial activity to both types of bacteria, more significant being on Gram-negative bacteria(E. coli). In conclusion, the leaves extract of Sida schimperiana Hochst. ex A. Rich plant contains bioactive molecules thatare used in the reduction and stabilization of AgNPs as potential antibacterial agents.Keywords: Biosynthesis · Phytochemicals · Antimicrobial resistance · Medicinal plant · Resistant pathogens
Full Abstract:
The use of metal nanoparticles as antibiotics for resistant pathogens has become a current topic of research. Biosyn-thesized nanoparticles are promising drugs as antibacterial agents by inhibiting bacteria from infectious diseases. Thisstudy aimed at the synthesis and characterization of silver nanoparticles (AgNPs) from AgNO 3 solution and Sida schim-periana Hochst. ex A. Rich leaves extract. The synthesized AgNPs were characterized by Fourier Transform Infrared (FTIR),Ultraviolet–Visible (UV–Vis) and X-ray diffraction (XRD) spectroscopic techniques and evaluated for antibacterial activi-ties against Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Escherichia coliand Klebsiella Pneumonia) bacteria by the disc diffusion method. The result indicated an initial color change that wasobserved below 400 nm for the leaves extract and 429 nm for AgNPs in the UV–Vis band supporting the synthesis ofsilver nanoparticles. The FTIR peaks at 3447, 1638 and 1413 cm −1 predict the hydroxyl, carbonyl and unsaturated C–Cbonds, respectively, in the plant leaves extract. The XRD analysis showed that the synthesized AgNPs were crystalline innature and face-centered cubic (FCC) structure with an average particle size of 26.27 nm. Furthermore, the synthesizednanoparticles showed antimicrobial activity to both types of bacteria, more significant being on Gram-negative bacteria(E. coli). In conclusion, the leaves extract of Sida schimperiana Hochst. ex A. Rich plant contains bioactive molecules thatare used in the reduction and stabilization of AgNPs as potential antibacterial agents.Keywords: Biosynthesis · Phytochemicals · Antimicrobial resistance · Medicinal plant · Resistant pathogens
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Green Voltammetric Strategy for Sensitive Determination of Paracetamol in Pharmaceuticals and Serum Using Alizarin Red S-Modified Glassy Carbon Electrodes
Journal Article
Wudneh Girum, Adane Kassa Submitted: Apr 17, 2025
Natural & Computational Sciences Chemistry
Abstract Preview:
This study introduces a highly sensitive electrochemical method for detecting paracetamol (PCT) in pharma-ceutical tablets and human serum samples, utilizing a glassy carbon electrode modified with alizarin red S (poly(ARS)/GCE). PCT is one of the most widely used analgesic and antipyretic drugs; however, its overdose orprolonged use can lead to severe liver and kidney damage. Therefore, the development of sensitive and reliablemethods for monitoring PCT levels in pharmaceutical formulations and biological fluids is crucial for ensuringdrug safety and effective therapeutic monitoring. Characterization of the electrode confirmed that the surfacemodification with a conductive and electroactive polymer film (poly(ARS)) significantly enhanced the effectiveelectrode surface area and reduced charge transfer resistance. Compared to the unmodified electrode, themodified electrode exhibited a well-resolved, irreversible redox peak at a significantly lower potential with asixfold increase in current, highlighting the catalytic efficiency of the modifier toward PCT. The electrochemicalbehavior of PCT was analyzed via cyclic voltammetry and square wave voltammetry, revealing significantlyenhanced sensitivity and selectivity due to the conductive polymer coating. Under optimized electrode conditionsquare wave voltammetric current response of poly(ARS)/GCE showed linear dependence on concentration of0.01–250.0 μM and an ultralow detection limit of 1.0 nM in phosphate buffer solution (pH 7.0). Analyticalapplication on real samples confirmed the method's accuracy, achieving recovery rates of 98.8–100.3 % forpharmaceutical tablets and human blood serum, even in the presence of potential interferents. The developedmethod provides a cost-effective and robust alternative for PCT quantification, with superior performancecompared to previously report electrochemical approaches.
Keywords: Paracetamol, Glassy carbon electrode, Alizarin red S, Cyclic voltammetry, Square wave voltammetry
Full Abstract:
This study introduces a highly sensitive electrochemical method for detecting paracetamol (PCT) in pharma-ceutical tablets and human serum samples, utilizing a glassy carbon electrode modified with alizarin red S (poly(ARS)/GCE). PCT is one of the most widely used analgesic and antipyretic drugs; however, its overdose orprolonged use can lead to severe liver and kidney damage. Therefore, the development of sensitive and reliablemethods for monitoring PCT levels in pharmaceutical formulations and biological fluids is crucial for ensuringdrug safety and effective therapeutic monitoring. Characterization of the electrode confirmed that the surfacemodification with a conductive and electroactive polymer film (poly(ARS)) significantly enhanced the effectiveelectrode surface area and reduced charge transfer resistance. Compared to the unmodified electrode, themodified electrode exhibited a well-resolved, irreversible redox peak at a significantly lower potential with asixfold increase in current, highlighting the catalytic efficiency of the modifier toward PCT. The electrochemicalbehavior of PCT was analyzed via cyclic voltammetry and square wave voltammetry, revealing significantlyenhanced sensitivity and selectivity due to the conductive polymer coating. Under optimized electrode conditionsquare wave voltammetric current response of poly(ARS)/GCE showed linear dependence on concentration of0.01–250.0 μM and an ultralow detection limit of 1.0 nM in phosphate buffer solution (pH 7.0). Analyticalapplication on real samples confirmed the method's accuracy, achieving recovery rates of 98.8–100.3 % forpharmaceutical tablets and human blood serum, even in the presence of potential interferents. The developedmethod provides a cost-effective and robust alternative for PCT quantification, with superior performancecompared to previously report electrochemical approaches.
Keywords: Paracetamol, Glassy carbon electrode, Alizarin red S, Cyclic voltammetry, Square wave voltammetry
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Groundwater Potential Zonation Mapping Using GIS-Based MCDM Approach in East Gojjam Zone, Central Ethiopia
Journal Article
Chalachew Tesfa *, Demeke Sewnet Submitted: Jun 05, 2025
Institute of Technology Civil Engineering
Abstract Preview:
Study region: The study area is located in the East Gojjam zone, Amhara, Ethiopia; the area coversthe Choke Mount and is surrounded by the Abbay River.Study focus: The primary focus of the study was assessing the possible groundwater sites in theselected area using the Analytical Hierarchy Process (AHP) with the Geographic InformationSystem (GIS) approach for groundwater exploration and investigation.New hydrological insights for the region: Water is a very important resource used to the day-to-dayactivities in our life, which is found naturally on the surface and subsurface of the Earth. Thestudy area is a part of a nation-wide economically significant region in Ethiopia and the Horn. Thearea is the primary water supply (Choke Mountain) for the Ethiopian Grand Ethiopian Renais-sance Dam (GERD) receives the highest water supply from this region. The results of the studyshow that the groundwater potential zones in the area are mapped as poor, moderate, high, andvery high groundwater potential areas. The Validations of the results were made using theborehole log data, and reasonably accepted the rationality of the adopted methodology. Theconsidered parameters, as well as their evaluation of the production of the groundwater potentialMap, were confirmed. The produced Groundwater potential map is very important for IrrigationEngineers, domestic water supply studies, agricultural studies, environmentalists, and futuregroundwater conservation strategies.
Keywords: GIS, AHP, Groundwater potentials, East Gojjam, Ethiopia
Full Abstract:
Study region: The study area is located in the East Gojjam zone, Amhara, Ethiopia; the area coversthe Choke Mount and is surrounded by the Abbay River.Study focus: The primary focus of the study was assessing the possible groundwater sites in theselected area using the Analytical Hierarchy Process (AHP) with the Geographic InformationSystem (GIS) approach for groundwater exploration and investigation.New hydrological insights for the region: Water is a very important resource used to the day-to-dayactivities in our life, which is found naturally on the surface and subsurface of the Earth. Thestudy area is a part of a nation-wide economically significant region in Ethiopia and the Horn. Thearea is the primary water supply (Choke Mountain) for the Ethiopian Grand Ethiopian Renais-sance Dam (GERD) receives the highest water supply from this region. The results of the studyshow that the groundwater potential zones in the area are mapped as poor, moderate, high, andvery high groundwater potential areas. The Validations of the results were made using theborehole log data, and reasonably accepted the rationality of the adopted methodology. Theconsidered parameters, as well as their evaluation of the production of the groundwater potentialMap, were confirmed. The produced Groundwater potential map is very important for IrrigationEngineers, domestic water supply studies, agricultural studies, environmentalists, and futuregroundwater conservation strategies.
Keywords: GIS, AHP, Groundwater potentials, East Gojjam, Ethiopia
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Growth monitoring and promotion service utilization and its associated factors among children less than two years in Ethiopia: A systematic review and meta-analysis
Research Paper
Mulat Belay Simegn1*, Werkneh Melkie Tilahun1 , Elyas Melaku Mazengia1 , Aysheshim Belaineh Haimanot1 , Anteneh Lamesgen Mneneh1 , Muluye Gebrie Mengie1 , Bekalu Endalew1 , Molla Yigzaw Birhanu1 , Tigabu Kidie Tesfie2, Lakew Asmare3 , Habtamu Geremew4 Submitted: Oct 06, 2025
College of Health Science Public Health
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Introduction: Growth monitoring and promotion services are strategies to promote child health and reduce child mortality. Even though Ethiopia is attempting different strategies to cope with the low rate of GMP utilization, the problem is still unresolved.
Objective: Determine the pooled proportion of GMP utilization and its contributing factors among children less than two years in Ethiopia.
Method: The review protocol was registered with PROSPERO, number CRD42023472746. The PRISMA-2020 statement guided the conduct of this review. Electronic databases and grey literature were used. Heterogeneity was evaluated using I2. Subgroup analysis was conducted. The random effect model was used to summarize the pooled effect sizes with their respective 95% CI with STATA version 17. To test the small study effect, the funnel plot and Egger’s test were applied.
Full Abstract:
Introduction: Growth monitoring and promotion services are strategies to promote child health and reduce child mortality. Even though Ethiopia is attempting different strategies to cope with the low rate of GMP utilization, the problem is still unresolved.
Objective: Determine the pooled proportion of GMP utilization and its contributing factors among children less than two years in Ethiopia.
Method: The review protocol was registered with PROSPERO, number CRD42023472746. The PRISMA-2020 statement guided the conduct of this review. Electronic databases and grey literature were used. Heterogeneity was evaluated using I2. Subgroup analysis was conducted. The random effect model was used to summarize the pooled effect sizes with their respective 95% CI with STATA version 17. To test the small study effect, the funnel plot and Egger’s test were applied.
Result: A total of seven (7) studies with 4027 participants were considered in this meta-analysis. The pooled proportion of GMP utilization reported by seven studies was 25.71% (95%CI: 24.39, 27.04). ANC follow-up (AOR = 2.11; 95% CI: 1.47, 2.76), PNC follow-up (AOR = 1.96; 95% CI: 1.44, 2.49), counseling (AOR = 2.88; 95% CI: 2.09, 3.68), maternal education (AOR = 2.89; 95% CI: 1.66, 4.13), paternal education (AOR = 3.78; 95% CI: 2.25, 5.32), family health card (AOR = 2.31; 95% CI: 1.67, 2.96), and mothers good knowledge towards GMP (AOR = 2.90; 95% CI: 1.72, 4.07) variables were positively associated with GMP service utilization.
Conclusion and recommendation: The pooled proportion of GMP remains low in Ethiopia. ANC and PNC follow-up, counseling, maternal and paternal education, family health cards, maternal knowledge towards GMP were significantly associated. Findings are essential for evidence-based policy making, intervention, and input for ongoing research.
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