Introduction Nurse burnout negatively impacts patient care quality, safety, and outcomes, while harming nurses’mental health, job satisfaction, and retention. It also imposes financial burdens on healthcare organizations throughabsenteeism, reduced productivity, and higher turnover costs, highlighting the need for research to address thesechallenges. The umbrella review methodology was selected to integrate evidence from multiple systematic reviewsand meta-analyses, offering a broad and in-depth summary of existing research to guide practice and policy. Thisapproach equips stakeholders with a holistic understanding of the multifaceted impacts of nurse burnout, facilitatingthe design of effective interventions that support nurses, enhance healthcare delivery, and optimize patientoutcomes. Consequently, this umbrella review aims to evaluate the global prevalence and contributing factors ofnurse burnout.Methods This umbrella review included 14 systematic reviews and meta-analyses identified from various databases.The quality of each study was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR II). Data wereextracted using Microsoft Excel and analyzed with STATA 17.0. Heterogeneity was measured using Higgin’s I2 Statistics,and summary prevalence estimates were calculated with the Der Simonian-Laird random-effects model. Meta-regression and subgroup analyses were conducted to identify the source of high heterogeneity. Publication bias wasassessed using funnel plots and Egger’s regression test, with the former providing a visual assessment of bias and thelatter offering a statistical method to detect asymmetry.Results The global prevalence of nurse burnout was evaluated in three areas: emotional exhaustion (33.45%, 95%CI 27.31–39.59), depersonalization (25.0%, 95% CI 17.17-33.00), and low personal accomplishment (33.49%, 95% CI28.43–38.55). Emotional exhaustion was most common among nurses working during the COVID-19 pandemic(39.23%, 95% CI 16.22–94.68). Oncology nurses experienced the highest rate of depersonalization (42%, 95% CI16.71–77.30), while nurses in intensive care units reported the highest rate of low personal accomplishment (46.02%,95% CI 43.83–48.28).
Conclusions Nurse burnout is prevalent worldwide, often marked by a sense of low personal accomplishment.Several factors contribute to this issue, including role conflict, negative emotions, family problems, moral distress,stress, commuting distance, predictability of work tasks, and workplace advancement.Keywords Nurse, Burnout, Determinant factors, And umbrella review

Introduction Depression and anxiety are prevalent psychological disorders that significantly affect physical,emotional, and social well-being, reducing quality of life and increasing medical costs. These issues are especiallychallenging for cancer survivors, complicating treatment management, affecting adherence, and potentiallyimpacting survival rates. Thus, this umbrella review aimed to evaluate the global prevalence of pain, depression, andanxiety, as well as their determinants among cancer patients.Method An exhaustive umbrella review was conducted to systematically assess the prevalence and determinants ofpain, depression, and anxiety among cancer survivors worldwide by analyzing systematic reviews and meta-analyses.The review involved a thorough search of multiple databases and included studies published in English up to July2024 that reported on these symptoms. The process involved screening and selecting studies based on specificcriteria, assessing the risk of bias using the AMSTAR tool, and analyzing data with statistical methods to determineoverall prevalence and identify predictors. This comprehensive approach aimed to provide a detailed understandingof these psychological issues in cancer survivors and guide future research and interventions.Result The global summary prevalence of depression among cancer survivors was 33.16% (95% CI 27.59–38.74),while anxiety had a prevalence of 30.55% (95% CI 24.04–37.06). Pain prevalence after treatment was 39.77% (95%CI 31.84–47.70). Before treatment, 65.22% (95% CI 62.86–67.57) of cancer patients reported pain, which persistedin 51.34% (95% CI 40.01–62.67) during treatment. The analysis also found that during the COVID-19 pandemic,depression and anxiety rates among cancer patients were at their highest, with prevalences of 43.25% (95% CI41.25–45.26) and 52.93% (95% CI 50.91–54.96), respectively.Conclusion The umbrella review found that depression and anxiety prevalence among cancer survivors was33.16% and 30.55%, respectively, with significantly higher rates during COVID-19 at 43.25% and 52.93%. Key factorscontributing to depression included poor social support, advanced cancer stage, and inadequate sleep, while anxietywas significantly linked to advanced cancer stage and poor sleep quality.
Clinical trial number Not applicable.Keywords Cancer, Oncology, Pain, Depression, Anxiety, Cancer survivors, Systematic review, Meta-analysis, Umbrellareview

The use of metal nanoparticles as antibiotics for resistant pathogens has become a current topic of research. Biosyn-thesized nanoparticles are promising drugs as antibacterial agents by inhibiting bacteria from infectious diseases. Thisstudy aimed at the synthesis and characterization of silver nanoparticles (AgNPs) from AgNO 3 solution and Sida schim-periana Hochst. ex A. Rich leaves extract. The synthesized AgNPs were characterized by Fourier Transform Infrared (FTIR),Ultraviolet–Visible (UV–Vis) and X-ray diffraction (XRD) spectroscopic techniques and evaluated for antibacterial activi-ties against Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Escherichia coliand Klebsiella Pneumonia) bacteria by the disc diffusion method. The result indicated an initial color change that wasobserved below 400 nm for the leaves extract and 429 nm for AgNPs in the UV–Vis band supporting the synthesis ofsilver nanoparticles. The FTIR peaks at 3447, 1638 and 1413 cm −1 predict the hydroxyl, carbonyl and unsaturated C–Cbonds, respectively, in the plant leaves extract. The XRD analysis showed that the synthesized AgNPs were crystalline innature and face-centered cubic (FCC) structure with an average particle size of 26.27 nm. Furthermore, the synthesizednanoparticles showed antimicrobial activity to both types of bacteria, more significant being on Gram-negative bacteria(E. coli). In conclusion, the leaves extract of Sida schimperiana Hochst. ex A. Rich plant contains bioactive molecules thatare used in the reduction and stabilization of AgNPs as potential antibacterial agents.Keywords: Biosynthesis · Phytochemicals · Antimicrobial resistance · Medicinal plant · Resistant pathogens

This study introduces a highly sensitive electrochemical method for detecting paracetamol (PCT) in pharma-ceutical tablets and human serum samples, utilizing a glassy carbon electrode modified with alizarin red S (poly(ARS)/GCE). PCT is one of the most widely used analgesic and antipyretic drugs; however, its overdose orprolonged use can lead to severe liver and kidney damage. Therefore, the development of sensitive and reliablemethods for monitoring PCT levels in pharmaceutical formulations and biological fluids is crucial for ensuringdrug safety and effective therapeutic monitoring. Characterization of the electrode confirmed that the surfacemodification with a conductive and electroactive polymer film (poly(ARS)) significantly enhanced the effectiveelectrode surface area and reduced charge transfer resistance. Compared to the unmodified electrode, themodified electrode exhibited a well-resolved, irreversible redox peak at a significantly lower potential with asixfold increase in current, highlighting the catalytic efficiency of the modifier toward PCT. The electrochemicalbehavior of PCT was analyzed via cyclic voltammetry and square wave voltammetry, revealing significantlyenhanced sensitivity and selectivity due to the conductive polymer coating. Under optimized electrode conditionsquare wave voltammetric current response of poly(ARS)/GCE showed linear dependence on concentration of0.01–250.0 μM and an ultralow detection limit of 1.0 nM in phosphate buffer solution (pH 7.0). Analyticalapplication on real samples confirmed the method's accuracy, achieving recovery rates of 98.8–100.3 % forpharmaceutical tablets and human blood serum, even in the presence of potential interferents. The developedmethod provides a cost-effective and robust alternative for PCT quantification, with superior performancecompared to previously report electrochemical approaches.
Keywords: Paracetamol, Glassy carbon electrode, Alizarin red S, Cyclic voltammetry, Square wave voltammetry

Introduction: Growth monitoring and promotion services are strategies to promote child health and reduce child mortality. Even though Ethiopia is attempting different strategies to cope with the low rate of GMP utilization, the problem is still unresolved.
Objective: Determine the pooled proportion of GMP utilization and its contributing factors among children less than two years in Ethiopia.
Method: The review protocol was registered with PROSPERO, number CRD42023472746. The PRISMA-2020 statement guided the conduct of this review. Electronic databases and grey literature were used. Heterogeneity was evaluated using I2. Subgroup analysis was conducted. The random effect model was used to summarize the pooled effect sizes with their respective 95% CI with STATA version 17. To test the small study effect, the funnel plot and Egger’s test were applied.
Result: A total of seven (7) studies with 4027 participants were considered in this meta-analysis. The pooled proportion of GMP utilization reported by seven studies was 25.71% (95%CI: 24.39, 27.04). ANC follow-up (AOR = 2.11; 95% CI: 1.47, 2.76), PNC follow-up (AOR = 1.96; 95% CI: 1.44, 2.49), counseling (AOR = 2.88; 95% CI: 2.09, 3.68), maternal education (AOR = 2.89; 95% CI: 1.66, 4.13), paternal education (AOR = 3.78; 95% CI: 2.25, 5.32), family health card (AOR = 2.31; 95% CI: 1.67, 2.96), and mothers good knowledge towards GMP (AOR = 2.90; 95% CI: 1.72, 4.07) variables were positively associated with GMP service utilization.
Conclusion and recommendation: The pooled proportion of GMP remains low in Ethiopia. ANC and PNC follow-up, counseling, maternal and paternal education, family health cards, maternal knowledge towards GMP were significantly associated. Findings are essential for evidence-based policy making, intervention, and input for ongoing research.

Habesha kemis, an Ethiopian attire traditionally donned by women belonging to the Habeshacommunity, has undergone variations of designs over time. Initially, it comprised a lengthy dresswith a fitted bodice and sleeves extending to the ankles. In the Amhara region, various ethnic groupssuch as Gojjam, Gondar, Shewa, Agew, and Wollo uphold their distinct cultural customs. While theseHabesha garments may appear similar outwardly, their embroidered motifs exhibit unique patterns,shapes, and hues, symbolizing the rich cultural legacy of Gojjam, Gondar, Shewa, Agew, and Wollo.The study aimed to identify the most appropriate model for recognizing and classifying the quality ofHabesha kemis embroidery design. Digital image processing methods and CNN models incorporatingVGG16, VGG19, and ResNet50v2 classifiers were used. Following the gathering of datasets,image preprocessing and segmentation were employed to enhance the model’s performance. Insegmentation, we used canny edge detection, local binary pattern, and dilation with contour detectionfor segmenting and automatically cropping each habesha kemis. After applying the segmentationprocess, the individual habesha kemis and foreign matters are placed in a folder based on theircorresponding categories. This resulted in 320 images before augmenting for each class amountrepresentative. The performance of VGG16, VGG19, and ResNet50v2 for Agew, Gojjam, Gonder,Shewa, and Wollo was evaluated. This process resulted in an image size of 224 × 224 in the CNNmodel with a VGG16 architecture and a SoftMax classifier of course we try also 64 × 64 and 128 × 128.Augmentation techniques were applied to increase the dataset size from 1600 to 3,270. Finally, themodel was evaluated and achieved an accuracy of 95.72% in test data and 99.62% in training datacompared to the VGG19 and ResNet50v2 models.Keywords Ethiopian cultural cloth, Habesha kemis, Embroidery design, Shemma

Background: Digital health data hubs contribute significantly to finding the right solutions to health problems, which forms the basis for achieving sustainable development goals. However, in Ethiopia, the health system has been coming to one central hub for all data, there is limited evidence of health professionals' intentions to use these systems. Understanding their intentions is crucial, as this can significantly improve the advancement of digital health in healthcare organizations. This study assessed health professionals' intention to use digital health data hubs in hospitals in East Gojjam, northwest Ethiopia, in 2024.
Methods: A cross-sectional study design was used to conduct the study. Eleven hospitals were included in the study area. Using an a priori structural equation modeling sample size calculator, the total sample size was 616. Stratified proportional allocation sampling was performed. The study participants were selected using a systematic sample. Structural equation modeling (SEM) was used for the analysis. Because it is a more powerful multivariate technique for testing and evaluating multivariate causal relationships. The assumptions of SEM-like normality, average variance extracted (AVE), composite reliability (CR), Cronbach's alpha, confirmatory factor analysis (CFA), and model specifications were checked using Amos and Stata version 16.
Results: This study was conducted with a sample size of 616 healthcare professionals; 591 (95.94%) responded to the survey. The results showed that 57.69% (n = 341) of the healthcare professionals intended to use the digital health data hub. Further analysis showed that perceived usefulness (PU: β = 0.576, p = 0.000), perceived trust (PT: β = 0.116, p = 0.022), and attitude (β = 0.143, p = 0.043) significantly and positively influenced health professionals' intention to use digital health data hubs.
Conclusion: Overall, the findings showed that 42.31% of health professionals have low intention to use digital health data hubs. These shall be needed to improve their intentions to use digital health data hubs through targeted interventions. Therefore, focusing on critical factors, such as perceived usefulness, trust, and attitude are crucial factors to reinforce their intention to use the system. Additionally, overcoming implementation challenges and building trust is critical to the successful integration and use of digital health data hubs.

Introduction: Promoting healthy lifestyle behaviors during pregnancy is a crucial health promotion strategy that could reduce pregnancy-related complications that may harm women and their fetuses. However, very few studies have assessed the prevalence of health-promoting lifestyle behaviors among pregnant women in Ethiopia. This study aimed to evaluate the extent and associated factors of health-promoting lifestyle behaviors among pregnant women in public health institutions in Debre Markos, northwest Ethiopia.
Methods: An institutional-based cross-sectional study was conducted among 275 pregnant women who were recruited using a systematic random sampling technique from 19 April to 19 May 2021. A face-to-face interview-administered questionnaire was used to collect the data. The data were analyzed using SPSS version 25. Multivariable binary logistic regression was used to identify the factors associated with the outcome variable. adjusted odds ratio (AOR), with a 95% confidence interval (CI) were used to measure the strength of the associations at a p-value

ABSTRACT: β-Lactam antibiotics are employed to treat bacterial illnesses.Despite a high level of clinical success, they have encountered serious resistancethat demands a high-dose regimen and a new pharmacokinetic combination. Thisrequires continuous monitoring of their levels in pharmaceutical and biologicalsamples. In this study, an electrochemical sensor was developed for thedetermination of cephalexin (CLN) in pharmaceutical formulations and biologicalfluid samples. The sensors were developed by modifying a glassy carbon electrode(GCE) using a conducting polymer (dipicrylamine) by potentiodynamicelectropolymerization. Characterization (using cyclic voltammetry and electronimpedance spectroscopy) results revealed modification of the electrode surface,leading to an enhanced effective electrode surface area and their conductivity. Theappearance of an irreversible oxidative peak at much-reduced potential with 5-foldcurrent enhancement at a poly(dipicrylamine)-modified glassy carbon electrode(poly(DPA)/GCE) verified the electrocatalytic role toward CLN. Under optimizedconditions, a wider linear concentration range (5 × 10−8 to 3.0 × 10−4 M), lowest limit of detection (LoD) (2.5 nM), detectedamount of each tablet brand above 97.00% of the labeled value (showing excellent agreement between the detected amount andcompany label), and excellent % recovery results in pharmaceutical and biological samples were obtained with an excellentinterference recovery error of less than 4.05%. Its excellent accuracy, selectivity, reproducibility, and stabilities and only requiring asimple electrode modification step combined with its readily available and nontoxic modifier, which sets it apart from mostpreviously reported methods, have validated the present method’s potential applicability for determining CLN in biological andpharmaceutical samples.

Accurate regulation of the liquid level in a quadruple tank system (QTS) is not easy and imposes higherrequirements on control strategies, so the design of controllers in these systems is challenging dueto the difficulty of dynamic analysis of its nonlinear characteristics and parametric uncertainties.To overcome these problems in liquid level regulation and increase the robustness to the pumpcoefficients, this article proposes and investigates the use of an optimal hybrid fractional-ordertype-2 fuzzy-PID (OH-FO-T2F-PID) regulator using a combination of two bio-inspired evolutionaryoptimizers, namely augmented grey wolf optimizer and cuckoo search optimizer, which gives rise tothe new hybrid A-GWOCS algorithm. This control mechanism was chosen to facilitate the convergenceof the water liquids in the two tanks as quickly as possible to the corresponding required values. Inaddition, a collaborative optimization technique with several objectives is used to adjust the regulatorparameters. The capability and efficiency of the suggested regulator is first investigated throughcomputer simulation results and then confirmed by real-time control experimental results on the QTSbased on dSPACE 1104 computation engine. The findings showed that the suggested OH-FO-T2F-PIDregulator significantly outperformed both the optimized ADRC and the OH-FO-T1F-PID regulators.Specifically, it reduced the rising time by 17.02% and 95.21%, respectively, and the settling time by25.13% and 74.28%. Additionally, the designed OH-FO-T2F-PID regulator successfully eliminatedthe steady-state error and overshoot, enabling precise regulation of the QTS, and maintenance theliquid level at the desired set point under a wide range of working situations. The robustness of therecommended regulator is also studied by considering − 50% disturbance in the QTS parameters, andthe findings showed that the OH-FO-T2F-PID regulator is less susceptible to variations in parameters.Keywords: Quadruple tank system (QTS), Optimal hybrid fractional order type 2 fuzzy PID regulator,Hybrid A-GWOCSO algorithm, Multi-objective optimization, dSPACE 1104 computation engine