Background: Neisseria gonorrhoeae is the causative agent of gonorrhea and accounts for the majority of sexuallytransmitted infections globally. There are few studies on the prevalence and antimicrobial susceptibility patternsof N. gonorrhoeae in Ethiopia.Objective: This study aimed to assess the prevalence, antimicrobial susceptibility patterns, and associated factorsof N. gonorrhoeae.Method: A cross-sectional study was conducted among women attending Debre Markos town health institutions;in Northwest Ethiopia from June 1, 2022 to October 30, 2022. An endocervical swab was collected and culturedon Modified Thayer Martin medium. Antimicrobial susceptibility testing was performed using the modifiedKirby-Bauer disk diffusion technique for isolates, following Clinical and laboratory standards institute guidelines.Logistic regression was applied to show the relationship between dependent and independent variables. P-value

Background: Armed conflicts significantly disrupt healthcare systems, leading to infrastructure destruction, shortages of medical supplies, and reduced access to essential health services. The Amhara region has experienced prolonged conflict, raising concerns about its impact on healthcare delivery. Understanding the extent of these disruptions is crucial for informing policy responses and humanitarian interventions.
Objectives: This systematic review and meta-analysis aimed to assess the impact of armed conflict on healthcare delivery in the Amhara region.
Study design: Systematic review and meta-analysis.
Methods: Conducted between June 1 and July 10, 2024, this meta-analysis followed PRISMA guidelines. A comprehensive search was performed across PubMed/MEDLINE, EMBASE, CINAHL, Google Scholar, ScienceDirect, and the Cochrane Library. Eligible studies included English-language observational studies and grey literature addressing healthcare disruptions, infrastructure damage, and health crises. Data were analyzed using STATA Version 14, and study quality was assessed using a modified Newcastle-Ottawa Scale.
Results: Twelve studies, encompassing 12,037,279 participants, were included. The pooled prevalence of health impacts was 76.71 % (95 % CI: 76.63-76.78). The conflict rendered 60 % of healthcare facilities nonfunctional, disrupted medical supplies for 70 % of the population, and reduced service availability by 80 %. Chronic disease management, mental health services, maternal care, and immunization programs experienced significant declines. Subgroup analyses indicated a higher prevalence of health impacts in studies published after 2022 (70.72 %) compared to those published before 2022 (28.35 %).
Conclusion: Armed conflict in the Amhara region has severely disrupted healthcare services, leading to facility closures, medical supply shortages, and significant declines in essential health services. Urgent interventions are required to restore healthcare infrastructure and services.

Keywords:  Amhara; Armed conflict; Meta-analysis; Prevalence; Systematic review.

Introduction Depression and anxiety are prevalent psychological disorders that significantly affect physical,emotional, and social well-being, reducing quality of life and increasing medical costs. These issues are especiallychallenging for cancer survivors, complicating treatment management, affecting adherence, and potentiallyimpacting survival rates. Thus, this umbrella review aimed to evaluate the global prevalence of pain, depression, andanxiety, as well as their determinants among cancer patients.Method An exhaustive umbrella review was conducted to systematically assess the prevalence and determinants ofpain, depression, and anxiety among cancer survivors worldwide by analyzing systematic reviews and meta-analyses.The review involved a thorough search of multiple databases and included studies published in English up to July2024 that reported on these symptoms. The process involved screening and selecting studies based on specificcriteria, assessing the risk of bias using the AMSTAR tool, and analyzing data with statistical methods to determineoverall prevalence and identify predictors. This comprehensive approach aimed to provide a detailed understandingof these psychological issues in cancer survivors and guide future research and interventions.Result The global summary prevalence of depression among cancer survivors was 33.16% (95% CI 27.59–38.74),while anxiety had a prevalence of 30.55% (95% CI 24.04–37.06). Pain prevalence after treatment was 39.77% (95%CI 31.84–47.70). Before treatment, 65.22% (95% CI 62.86–67.57) of cancer patients reported pain, which persistedin 51.34% (95% CI 40.01–62.67) during treatment. The analysis also found that during the COVID-19 pandemic,depression and anxiety rates among cancer patients were at their highest, with prevalences of 43.25% (95% CI41.25–45.26) and 52.93% (95% CI 50.91–54.96), respectively.Conclusion The umbrella review found that depression and anxiety prevalence among cancer survivors was33.16% and 30.55%, respectively, with significantly higher rates during COVID-19 at 43.25% and 52.93%. Key factorscontributing to depression included poor social support, advanced cancer stage, and inadequate sleep, while anxietywas significantly linked to advanced cancer stage and poor sleep quality.
Clinical trial number Not applicable.Keywords Cancer, Oncology, Pain, Depression, Anxiety, Cancer survivors, Systematic review, Meta-analysis, Umbrellareview

Industries are among the largest global consumers of water, with a significant portion beingconverted into industrial wastewater. Paint factories, in particular, are major contributors toenvironmental lead pollution, releasing lead (II) through untreated effluents. Exposure to lead (II)poses serious health risks, including carcinogenic effects, neurological disorders, blood-relatedcomplications, and damage to vital organs such as the liver, kidneys, and lungs. While exten-sive research has focused on lead (II) removal from synthetic wastewater, limited studies haveaddressed the application of these methods to real industrial wastewater. This study aimed toevaluate the efficiency of Noug stalk activated carbon in removing lead (II) from paint factoryeffluent under optimized conditions. Laboratory experiments were conducted to assess the per-formance of Noug stalk activated carbon in treating wastewater from a paint factory. Statisticalanalysis using Statistical Package for Social Sciences version 20 was employed, with a pairedsample t-test determining the significance of differences in lead (II) concentrations before andafter treatment, considering a p-value of

Extreme flood and drought events arise from temporal and spatial variations in the Earth’s water cycle, signif-icantly affecting water resources and the environment. This review aimed to evaluate the effects of climatevariabilities on extreme flood and drought events within the Blue Nile Basin. A systematic literature review andcontent analysis were conducted to understand the hydrological dynamics of floods and droughts. A Scopusdatabase was used to find relevant literature review articles related to flood and drought extreme events usingsearch terms queries. The findings suggest that rising temperatures and fluctuating precipitation patterns areleading to more frequent and severe floods and droughts. Future projections also suggest increased droughtseverity in most basin areas, coupled with more frequent floods. Fluctuations between dry and wet conditionshave intensified these extremes. While insufficient rainfall triggers droughts, excessive and concentrated rainfallcontributes to floods. The wet projection shows more frequent floods, while the dry projection indicates severedroughts throughout most of the basin. This review provides a valuable starting point for further action towards amore climate-resilient and water-secure for sustainable environmental development and management over thebasin.
Keywords: BNB, Climate variability, Hydrological extremes, Water resource

The use of metal nanoparticles as antibiotics for resistant pathogens has become a current topic of research. Biosyn-thesized nanoparticles are promising drugs as antibacterial agents by inhibiting bacteria from infectious diseases. Thisstudy aimed at the synthesis and characterization of silver nanoparticles (AgNPs) from AgNO 3 solution and Sida schim-periana Hochst. ex A. Rich leaves extract. The synthesized AgNPs were characterized by Fourier Transform Infrared (FTIR),Ultraviolet–Visible (UV–Vis) and X-ray diffraction (XRD) spectroscopic techniques and evaluated for antibacterial activi-ties against Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Escherichia coliand Klebsiella Pneumonia) bacteria by the disc diffusion method. The result indicated an initial color change that wasobserved below 400 nm for the leaves extract and 429 nm for AgNPs in the UV–Vis band supporting the synthesis ofsilver nanoparticles. The FTIR peaks at 3447, 1638 and 1413 cm −1 predict the hydroxyl, carbonyl and unsaturated C–Cbonds, respectively, in the plant leaves extract. The XRD analysis showed that the synthesized AgNPs were crystalline innature and face-centered cubic (FCC) structure with an average particle size of 26.27 nm. Furthermore, the synthesizednanoparticles showed antimicrobial activity to both types of bacteria, more significant being on Gram-negative bacteria(E. coli). In conclusion, the leaves extract of Sida schimperiana Hochst. ex A. Rich plant contains bioactive molecules thatare used in the reduction and stabilization of AgNPs as potential antibacterial agents.Keywords: Biosynthesis · Phytochemicals · Antimicrobial resistance · Medicinal plant · Resistant pathogens

This study aims and documents the clinical and laboratory diagnosis of bovine dermatophilosis, caused by Dermatophiluscongolensis that causes exudation and matting of hairs and wools with the formation of crusts and scab. An adult local breed bullwith a history of reduced appetite, pruritus, dirty scabs and crusts as initial lesion coalesce on its different body parts was presentedto Debre Markos multipurpose veterinary clinic. The rectal temperature and other vital parameters were within the normalrange. The clinical signs observed were exudative dermatitis forming crusts and scabs, pruritus, matted hair like a paintbrushand keratinized material creating wart-like lesions that were widely distributed in different body parts. Few ticks were observedon the skin of the bull suspected as vector of the disease. Culture of skin scraps on blood agar showed small, grayish-white raisedgranular and hemolytic colonies. Staining of skin scraps by Giemsa and Gram’s stain and cultured colony by Gram’s stain indicatedthe characteristics of Dermatophilus congolensis, etiology of dermatophilosis. Other laboratory tests also showed the characteristicsof D. congolensis. The case was treated by penstrep and ivermectin parentally and iodine tincture topically, and the bull showedprogressive clinical improvement and complete recovery within 2 months. In conclusion, dermatophilosis is an economicallyimportant skin disease, highly prevalent in Ethiopia, and needs early detection and treatment by penstrep intramuscularly andivermectine subcutaneously with iodine tincture topically in line with proper husbandry practices to control the losses.
Keywords:  Dermatophilus congolensis; bull; clinical diagnosis; dermatophilosis; skin.

Introduction Protecting digital health data from unauthorized access, alteration, and destruction is a crucial aspectof healthcare digitalization. Currently, digital security breaches are becoming more common. Healthcare databreaches have compromised over 50 million medical records per year. In Ethiopia, health digitization has growngradually. However, there is a limitation of study in digital health security. Studying digital health data security helpsindividuals protect digital data as a baseline and contributes to developing a digital health security policy.Objective To assess the practice of healthcare professionals in digital health data security among specializedteaching referral hospitals in Amhara Region, Ethiopia.Method A cross-sectional study design supplemented by a qualitative purposive sampling method was usedto measure the digital data security practices of health professionals. The sample size was determined via singlepopulation proportion formula. A simple random sampling technique was used for the study participants. Then, self-administered questionnaires were administered. Multivariable logistic analysis was used to identify associated factorsusing STATA software. For the qualitative study, key informant interviews were used and analyzed using thematicanalysis approach via open-code software.Results Out of the 423 health professionals, 95.0% were involved in the survey. The finding indicates digital healthdata security practice of health professionals working at specialized teaching hospitals were 45.0%, CI: (40, 50). Healthprofessionals 41–45-year age group (AOR = 0.107), master’s degree (AOR = 2.45), postmaster’s degree (AOR = 3.87),time to visit the internet for more than two hours (AOR = 2.46), basic computer training (AOR = 2.77), training indigital data security (AOR = 2.14), and knowledge (AOR = 1.76) were associated with the practice of digital health datasecurity. For the qualitative study, three teams were prepared. The findings indicate digital health data security can beimproved through training, advanced knowledge and working with digital security.
Conclusion The practice of digital health data security in specialized teaching hospitals in the Amhara region wasinadequate. Therefore, it can be improved through enhancing education status, increasing the time needed to visitthe internet, providing computer training, and updating health professionals’ knowledge toward digital health datasecurity.Keywords Practice, Digital health, Digital data security, Health profession

Increasing greenhouse gas (GHG) emissions and environmental issues have heightened the demandfor renewable energy sources (RES) and prompted a swift transition to electric vehicles (EVs) in thetransportation sector. This shift underscores the need to address the challenges of electricity supplyand continuity for electric vehicle charging stations (EVCS). This study aims to determine the mostsuitable hybrid systems to ensure the electricity supply to EVCSs in the Çukurova region of Adana,Turkey. Six different scenarios involving components such as photovoltaic (PV) panel, wind turbine(WT), biomass generators (BG), electrolyzer (Elz), hydrogen tank (HT), fuel cell (FC), batteries (Bat),inverter (Inv), and the grid were analyzed using HOMER Pro microgrid analysis tool version 3.14.2software. The optimization results indicated that the most feasible system was Scenario 4, comprisingthe PV, BG, Elz, HT, FC, Inv, and grid components. This scenario’s total net present cost (NPC) was$611,283.50, with a levelized cost of energy (LCOE) of $0.0215. The annual energy productionand consumption were 1,507,169 kWh and 1,420,714 kWh, respectively. The fact that the energygenerated from exceeds the energy sourced from the grid reduces the payback period of the system.These findings highlight the economic and sustainable potential of renewable hybrid systems forenhancing the performance of EVCS in solar-rich regions.Keywords: Energy cost efficiency, Renewable energy integration, Electric vehicle charging stations, Hybridsystems, Optimization, Energy sustainability

Objectives: This study aimed to assess the prevalence and risk factors of intestinal schistosomiasis in students atBochesa Elementary School in the wetlands of Lake Ziway.Methods: A cross-sectional study of 384 students was conducted in May 2016. Intestinal schistosomiasis wasexamined using the Kato-Katz technique. For the association between the prevalence of intestinal schistosomiasisand categorical variables, the chi-square (𝜒2 ) test was used. A binary logistic regression was applied.Results: The overall prevalence of intestinal schistosomiasis was 25.52%. Males were more infected (17.45%)than women (8.07%), and the difference was significant (𝜒2 = 17.756; P