Time to first optimal glycemic control and its predictors among adult type 2 diabetes patients in Amhara Regional State comprehensive specialized hospitals, Northwest Ethiopia
Journal Article
Sintayehu Chalie1, Atsede Alle Ewunetie2, Moges Agazhe Assemie2, Atalay Liknaw2, Friehiwot Molla2, Animut Takele Telayneh2 and Bekalu Endalew
Aug 30, 2024
College of Health Science
Public Health
Abstract Preview:
Background Inadequate glycemic management in type 2 diabetes Mellitus patients is a serious public healthissue and a key risk factor for progression as well as diabetes-related complications. The main therapeutic goal ofpreventing organ damage and other problems caused by diabetes is glycemic control. Knowing when to modifyglycemic control in type 2 diabetes Mellitus is crucial for avoiding complications and early drug intensifications.Methods An institutional based retrospective follow-up study was undertaken among 514 eligible adult diabetespatients in Amhara region Comprehensive Specialized Hospitals, Northwest Ethiopia, from January 2017 to January2022. Simple random sampling technique was used to select study participants. The Kaplan Meier curve was usedto assess the survival status of categorical variables, and the log-rank test was used to compare them. The coxproportional hazard model was fitted to identify the predictors of time to first optimal glycemic control. Variables witha p-value < 0.05 were considered to be statistically significance at 95% confidence interval.Results A total of 514 patient records (227 males and 287 females) were reviewed in this study. The median time tofirst optimal glycemic control among the study population was 8.4 months IQR (7.6â9.7). The predictors that affect thetime to first optimal glycemic control were age group ((AHR = 0.63, 95% CI = 0.463, 0.859 for 50â59 years), (AHR = 0.638,95% CI = 0.471, 0.865 for 60â69 years), and (AHR = 0.480, 95% CI = 0.298, 0.774 for > = 70 years)), diabetes neuropathy(AHR = 0.629, 95% CI = 0.441,0.900), hypertension (AHR = 0.667, 95% CI = 0.524, 0.848), dyslipidemia (AHR = 0.561, 95%CI = 0.410, 0.768), and cardiovascular disease (AHR = 0.681, 95% CI = 0.494, 0.938).Conclusion The median time to initial optimal glycemic control in type 2 diabetes Mellitus patients in this study wasshort. Age between 50 and 59 years and 60â69, diabetes neuropathy, hypertension, dyslipidemia, and cardiovascular
disease were predictorâs of time to first glycemic control. Therefore, health care providers should pay extra attentionfor patients who are aged and who have complications or co-morbidities.Keywords:Â Adults, First optimal glycemic control, Type 2 diabetes mellitus, Ethiopia
Full Abstract:
Background Inadequate glycemic management in type 2 diabetes Mellitus patients is a serious public healthissue and a key risk factor for progression as well as diabetes-related complications. The main therapeutic goal ofpreventing organ damage and other problems caused by diabetes is glycemic control. Knowing when to modifyglycemic control in type 2 diabetes Mellitus is crucial for avoiding complications and early drug intensifications.Methods An institutional based retrospective follow-up study was undertaken among 514 eligible adult diabetespatients in Amhara region Comprehensive Specialized Hospitals, Northwest Ethiopia, from January 2017 to January2022. Simple random sampling technique was used to select study participants. The Kaplan Meier curve was usedto assess the survival status of categorical variables, and the log-rank test was used to compare them. The coxproportional hazard model was fitted to identify the predictors of time to first optimal glycemic control. Variables witha p-value < 0.05 were considered to be statistically significance at 95% confidence interval.Results A total of 514 patient records (227 males and 287 females) were reviewed in this study. The median time tofirst optimal glycemic control among the study population was 8.4 months IQR (7.6â9.7). The predictors that affect thetime to first optimal glycemic control were age group ((AHR = 0.63, 95% CI = 0.463, 0.859 for 50â59 years), (AHR = 0.638,95% CI = 0.471, 0.865 for 60â69 years), and (AHR = 0.480, 95% CI = 0.298, 0.774 for > = 70 years)), diabetes neuropathy(AHR = 0.629, 95% CI = 0.441,0.900), hypertension (AHR = 0.667, 95% CI = 0.524, 0.848), dyslipidemia (AHR = 0.561, 95%CI = 0.410, 0.768), and cardiovascular disease (AHR = 0.681, 95% CI = 0.494, 0.938).Conclusion The median time to initial optimal glycemic control in type 2 diabetes Mellitus patients in this study wasshort. Age between 50 and 59 years and 60â69, diabetes neuropathy, hypertension, dyslipidemia, and cardiovascular
disease were predictorâs of time to first glycemic control. Therefore, health care providers should pay extra attentionfor patients who are aged and who have complications or co-morbidities.Keywords:Â Adults, First optimal glycemic control, Type 2 diabetes mellitus, Ethiopia